8VZA
Crystal Structure of 2-Hydroxacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, L-Lactyl-CoA, and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 2-Hydroxyacyl-CoA lyase/Synthase | polymer | 560 | 59951.2 | 4 | UniProt (A0A3C0TX30) | Alphaproteobacteria bacterium | |
| 2 | E, K, P, V (A, B, C, D) | 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate | non-polymer | 442.3 | 4 | Chemie (8FL) | |||
| 3 | F, L, Q, W (A, B, C, D) | S-{(3S,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (2R)-2-hydroxypropanethioate | non-polymer | 839.6 | 4 | Chemie (UQ3) | |||
| 4 | G, M, S, X (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 5 | H, J, R, T (A, B, C) | ACETYL GROUP | non-polymer | 44.1 | 4 | Chemie (ACE) | |||
| 6 | I, O, U, Y (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 7 | N (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | AA, BA, CA, Z (B, C, D, A) | water | water | 18.0 | 790 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 554 (UniProt: A0A3C0TX30)
| PDB | External Database | Details |
|---|---|---|
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 239804.8 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 7202.0 | |
| All* | Total formula weight | 247006.8 |
