8VWX

Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to Maltose-Binding Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera	polymer	547	61302.9	1	UniProt (P0AEX9) UniProt (P10415) UniProt (Q07817) Pfam (PF01547) Pfam (PF02180) Pfam (PF00452)	Escherichia coli (strain K12)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Bcl2-L-1,Apoptosis regulator Bcl-X
2	B (A)	water	water		18.0	413	Chemie (HOH)

Sequence modifications

A: -362 - 3 (UniProt: P0AEX9)

PDB	External Database	Details
Met -380	-	initiating methionine
His -379	-	expression tag
His -378	-	expression tag
His -377	-	expression tag
His -376	-	expression tag
His -375	-	expression tag
His -374	-	expression tag
His -373	-	expression tag
His -372	-	expression tag
His -371	-	expression tag
His -370	-	expression tag
Glu -369	-	expression tag
Asn -368	-	expression tag
Leu -367	-	expression tag
Tyr -366	-	expression tag
Phe -365	-	expression tag
Gln -364	-	expression tag
Gly -363	-	expression tag
Ala -281	Asp 108	engineered mutation
Ala -280	Lys 109	engineered mutation
Ala -191	Glu 198	engineered mutation
Ala -190	Asn 199	engineered mutation
Ala -124	Lys 265	engineered mutation
Ala 4	-	linker
Ala 5	-	linker
Arg 6	-	linker
Ala 7	-	linker
Ala 8	-	linker
Ala 9	-	linker

A: 10 - 34 (UniProt: P10415)
A: 92 - 207 (UniProt: P10415)

PDB	External Database	Details
Val 101	Gly 101	engineered mutation

A: 76 - 91 (UniProt: Q07817)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	61302.9
All*	Total formula weight	61302.9

*Water molecules are not included.