8VW5

Crystal structure of Cbl-b TKB bound to compound 2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	E3 ubiquitin-protein ligase CBL-B	polymer	310	36205.5	1	UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762)	Homo sapiens (human)	Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B
2	B (B)	E3 ubiquitin-protein ligase CBL-B	polymer	310	36164.5	1	UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762)	Homo sapiens (human)	Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D, G (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	E, F (A, B)	[5-(2-{(2R,5S)-2-[2-(carboxymethoxy)-3-methoxy-5-nitrophenyl]-3,5-dimethyl-4-oxoimidazolidin-1-yl}-2-oxoethyl)-3,6-dimethoxy-9,9-dimethyl-9H-xanthen-4-yl]acetic acid	non-polymer		707.7	2	Chemie (A1AD4)
6	H, I (A, B)	water	water		18.0	616	Chemie (HOH)

Sequence modifications

A: 36 - 343 (UniProt: Q13191)

PDB	External Database	Details
Gly 34	-	expression tag
Ser 35	-	expression tag
Arg 91	Lys 91	conflict
Asn 136	Gln 136	conflict

B: 36 - 343 (UniProt: Q13191)

PDB	External Database	Details
Gly 34	-	expression tag
Ser 35	-	expression tag
Asn 136	Gln 136	conflict
Thr 170	Asn 170	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72370.1
Non-Polymers*	Number of molecules	5
	Total formula weight	1519.8
All*	Total formula weight	73889.9

*Water molecules are not included.