8VU5
Cryo-EM structure of MPL bound to TPO
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombopoietin | polymer | 170 | 18365.4 | 1 | UniProt (P40226) Pfam (PF00758) | Mus musculus (house mouse) | C-mpl ligand,ML,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,MGDF,Myeloproliferative leukemia virus oncogene ligand |
| 2 | B, C (B, C) | Thrombopoietin receptor | polymer | 463 | 52030.5 | 2 | UniProt (Q08351) Pfam (PF09067) | Mus musculus (house mouse) | TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl |
Sequence modifications
A: 22 - 184 (UniProt: P40226)
B, C: 26 - 482 (UniProt: Q08351)
| PDB | External Database | Details |
|---|---|---|
| Glu 185 | - | expression tag |
| Asn 186 | - | expression tag |
| Leu 187 | - | expression tag |
| Tyr 188 | - | expression tag |
| Phe 189 | - | expression tag |
| Gln 190 | - | expression tag |
| Gly 191 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 483 | - | expression tag |
| Asn 484 | - | expression tag |
| Leu 485 | - | expression tag |
| Tyr 486 | - | expression tag |
| Phe 487 | - | expression tag |
| Gln 488 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 122426.4 | |
| All* | Total formula weight | 122426.4 |
