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8VU5

Cryo-EM structure of MPL bound to TPO

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005179molecular_functionhormone activity
A0005576cellular_componentextracellular region
A0008283biological_processcell population proliferation
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00817
Number of Residues28
DetailsEPO_TPO Erythropoietin / thrombopoeitin signature. PvapaCDpRLLnKllrdshllhsrlsqC
ChainResidueDetails
APRO23-CYS50

site_idPS01352
Number of Residues78
DetailsHEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LeLeWqhqsswaaqetc....YQLrytgegredwkvlepslgarggtle..LrpraryslqlRaRlngptyqgpWsaWspparV
ChainResidueDetails
BLEU397-VAL474

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

250359

PDB entries from 2026-03-11

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