8VTI

Latrophilin-3 (ADGRL3) HormR and GAIN domains in the context of the holoreceptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 4 of Adhesion G protein-coupled receptor L3	polymer	375	41641.8	1	UniProt (Q9HAR2) Pfam (PF02793) Pfam (PF16489) Pfam (PF01825)	Homo sapiens (human)	Calcium-independent alpha-latrotoxin receptor 3,CIRL-3,Latrophilin-3,Lectomedin-3
2	B (B)	Isoform 4 of Adhesion G protein-coupled receptor L3	polymer	314	35839.3	1	UniProt (Q9HAR2) Pfam (PF00002) Pfam (PF02354)	Homo sapiens (human)	Calcium-independent alpha-latrotoxin receptor 3,CIRL-3,Latrophilin-3,Lectomedin-3
3	C (C)	sAB Light Chain	polymer	215	23329.9	1		synthetic construct
4	D (D)	sAB Heavy Chain	polymer	235	25221.0	1		synthetic construct
5	E (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 490 - 854 (UniProt: Q9HAR2)

PDB	External Database	Details
Asp 480	-	expression tag
Tyr 481	-	expression tag
Lys 482	-	expression tag
Asp 483	-	expression tag
Asp 484	-	expression tag
Asp 485	-	expression tag
Asp 486	-	expression tag
Ala 487	-	expression tag
Met 488	-	expression tag
Ala 489	-	expression tag

B: 855 - 1160 (UniProt: Q9HAR2)

PDB	External Database	Details
His 1161	-	expression tag
His 1162	-	expression tag
His 1163	-	expression tag
His 1164	-	expression tag
His 1165	-	expression tag
His 1166	-	expression tag
His 1167	-	expression tag
His 1168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	126031.9
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	126839.6

*Water molecules are not included.