8VTE

Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tiragolumab antibody light chain variable domains	polymer	220	24246.9	2		Mus musculus (house mouse)
2	B, D (B, D)	Tiragolumab antibody heavy chain variable domains	polymer	230	24696.5	2		Mus musculus (house mouse)
3	E, F (E, F)	T-cell immunoreceptor with Ig and ITIM domains	polymer	122	13413.9	2	UniProt (Q495A1) Pfam (PF07686)	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	425	Chemie (HOH)

Sequence modifications

E, F: 22 - 137 (UniProt: Q495A1)

PDB	External Database	Details
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124714.6
All*	Total formula weight	124714.6

*Water molecules are not included.