8VTD

Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Vibostolimab Fab Light chain	polymer	214	23508.2	1		Mus musculus (house mouse)
2	B (B)	Vibostolimab Fab Heavy chain	polymer	221	23569.3	1		Homo sapiens (human)
3	C (C)	T-cell immunoreceptor with Ig and ITIM domains	polymer	122	13413.9	1	UniProt (Q495A1) Pfam (PF07686)	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
4	D, E (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	F, G, H (A, B, C)	water	water		18.0	588	Chemie (HOH)

Sequence modifications

C: 22 - 137 (UniProt: Q495A1)

PDB	External Database	Details
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	60491.4
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	60675.6

*Water molecules are not included.