8VR9

Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide conjugate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HLA class I histocompatibility antigen, A alpha chain	polymer	278	32047.3	1	UniProt (P04439) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (human)	Human leukocyte antigen A,HLA-A
2	B	Beta-2-microglobulin	polymer	101	11892.3	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (human)
3	C	GTPase KRas, N-terminally processed	polymer	9	790.0	1	UniProt (P01116) In PDB	Homo sapiens
4	D	R023 Fab light chain	polymer	216	23518.2	1		Homo sapiens
5	E	R023 Fab heavy chain	polymer	228	24034.8	1		Homo sapiens
6	E	AMG 510 (bound form)	non-polymer		562.6	1	Chemie (MOV)

Sequence modifications

A: 1 - 275 (UniProt: P04439)

PDB	External Database	Details
Met -2	-	initiating methionine
Ala -1	-	expression tag
Ser 0	-	expression tag

B: 21 - 119 (UniProt: P61769)

PDB	External Database	Details
Gly 19	-	expression tag
Ser 20	-	expression tag

C: 8 - 16 (UniProt: P01116)

PDB	External Database	Details
Cys 12	Gly 12	variant

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	92282.6
Non-Polymers*	Number of molecules	1
	Total formula weight	562.6
All*	Total formula weight	92845.2

*Water molecules are not included.