8VQD
HER2 S310F in complex with TL1 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor tyrosine-protein kinase erbB-2/hIgG1 Fc domain fusion | polymer | 894 | 99261.6 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | B (C) | Variable Heavy chain of TL1 Fab | polymer | 257 | 27512.6 | 1 | Homo sapiens (human) | ||
| 3 | C (B) | Variable Light chain of TL1 Fab | polymer | 215 | 23339.9 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
A: 23 - 652 (UniProt: P04626)
A: 653 - 916 (PDB: 8VQD)
| PDB | External Database | Details |
|---|---|---|
| Phe 274 | Tyr 274 | conflict |
| Phe 310 | Ser 310 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 150114.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 150538.5 |
