8VP4

Crystal Structure of JF1cpCasp2 with Peptide Inhibitor AcVDVAD-CHO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	JF1cpCasp2	polymer	282	31705.2	2	UniProt (P42575) Pfam (PF00619)	Homo sapiens (human)
2	C, D (D, C)	AcVDVAD-CHO	polymer	6	527.6	2	BIRD (PRD_001048)	synthetic construct	AcVDVAD-CHO
3	E, F, G, H (A, B, D, C)	water	water		18.0	285	Chemie (HOH)

Sequence modifications

A, B: 334 - 1173 (UniProt: P42575)

PDB	External Database	Details
Met 327	-	initiating methionine
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
Ala 347	Asp 347	conflict

A, B: 1176 - 1333 (UniProt: P42575)

PDB	External Database	Details
Gly 1174	-	linker
Gly 1175	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	64465.6
All*	Total formula weight	64465.6

*Water molecules are not included.