8VME
Crystal structure of the GSK-3/Axin complex bound to a phosphorylated beta-catenin T41A peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glycogen synthase kinase-3 beta | polymer | 365 | 41666.8 | 1 | UniProt (Q9WV60) Pfam (PF00069) In PDB | Mus musculus (house mouse) | GSK-3 beta,Serine/threonine-protein kinase GSK3B |
| 2 | B | Axin-1 | polymer | 24 | 2738.1 | 1 | UniProt (O35625) In PDB | Homo sapiens (human) | Axis inhibition protein 1,Protein Fused |
| 3 | C | Catenin beta-1 | polymer | 28 | 2912.0 | 1 | UniProt (P35222) In PDB | Homo sapiens (human) | Beta-catenin |
| 4 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | A | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 7 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 26 - 383 (UniProt: Q9WV60)
B: 383 - 402 (UniProt: O35625)
C: 35 - 61 (UniProt: P35222)
| PDB | External Database | Details |
|---|---|---|
| Gln 25 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Ile 381 | - | expression tag |
| Leu 382 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 34 | - | initiating methionine |
| Ala 41 | Thr 41 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 47316.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1051.4 | |
| All* | Total formula weight | 48368.3 |
