8V7W

Room-temperature X-ray structure of SARS-CoV-2 main protease catalytic domain C145A precursor, residues nsp4(-6)-1-199-6H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Replicase polyprotein 1ab	polymer	215	23689.9	2	UniProt (P0DTD1) Pfam (PF05409)	Severe acute respiratory syndrome coronavirus 2	pp1ab,ORF1ab polyprotein
2	C, D (A, B)	water	water		18.0	130	Chemie (HOH)

Sequence modifications

A, B: -5 - 199 (UniProt: P0DTD1)

PDB	External Database	Details
Ser -7	-	expression tag
Gly -6	-	expression tag
Ala 145	Cys 3408	engineered mutation
Leu 200	-	expression tag
Glu 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47379.8
All*	Total formula weight	47379.8

*Water molecules are not included.