8V42
Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Serine/threonine-protein kinase VRK1 | polymer | 364 | 41138.1 | 4 | UniProt (Q99986) In PDB | Homo sapiens (human) | Vaccinia-related kinase 1 |
2 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
3 | B, D | (7S)-2-(3,5-difluoro-4-hydroxyanilino)-7-methyl-5-[(1,2-oxazol-5-yl)methyl]-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one | non-polymer | 426.4 | 2 | Chemie (YD9) | |||
4 | C, D | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
5 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 364 (UniProt: Q99986)
PDB | External Database | Details |
---|---|---|
Ser 1 | - | expression tag |
Met 2 | - | expression tag |
Ala 34 | Lys 34 | engineered mutation |
Ala 35 | Lys 35 | engineered mutation |
Ala 36 | Glu 36 | engineered mutation |
Ala 212 | Glu 212 | engineered mutation |
Ala 214 | Lys 214 | engineered mutation |
Ala 215 | Glu 215 | engineered mutation |
Ala 292 | Glu 292 | engineered mutation |
Ala 293 | Lys 293 | engineered mutation |
Ala 295 | Lys 295 | engineered mutation |
Ala 359 | Lys 359 | engineered mutation |
Ala 360 | Lys 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 164552.5 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1343.1 | |
All* | Total formula weight | 165895.6 |