8V42
Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGGFGCIYlAdmnssesvgsdap.....CVVK |
| Chain | Residue | Details |
| A | ILE43-LYS71 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHgDIKasNLLL |
| Chain | Residue | Details |
| A | TYR173-LEU185 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP177 | |
| B | ASP177 | |
| C | ASP177 | |
| D | ASP177 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE43 | |
| A | LYS71 | |
| B | ILE43 | |
| B | LYS71 | |
| C | ILE43 | |
| C | LYS71 | |
| D | ILE43 | |
| D | LYS71 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:19103756, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER342 | |
| B | SER342 | |
| C | SER342 | |
| D | SER342 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11883897 |
| Chain | Residue | Details |
| A | THR355 | |
| B | THR355 | |
| C | THR355 | |
| D | THR355 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS71 | |
| B | LYS71 | |
| C | LYS71 | |
| D | LYS71 |
