8V42
Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 29 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGGFGCIYlAdmnssesvgsdap.....CVVK |
Chain | Residue | Details |
A | ILE43-LYS71 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHgDIKasNLLL |
Chain | Residue | Details |
A | TYR173-LEU185 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP177 | |
B | ASP177 | |
C | ASP177 | |
D | ASP177 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | ILE43 | |
A | LYS71 | |
B | ILE43 | |
B | LYS71 | |
C | ILE43 | |
C | LYS71 | |
D | ILE43 | |
D | LYS71 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:19103756, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER342 | |
B | SER342 | |
C | SER342 | |
D | SER342 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11883897 |
Chain | Residue | Details |
A | THR355 | |
B | THR355 | |
C | THR355 | |
D | THR355 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS71 | |
B | LYS71 | |
C | LYS71 | |
D | LYS71 |