8V2A
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Oncostatin-M | polymer | 196 | 22186.4 | 1 | UniProt (P13725) Pfam (PF01291) | Homo sapiens (human) | |
| 2 | B (B) | Interleukin-6 receptor subunit beta | polymer | 625 | 71233.2 | 1 | UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041) | Homo sapiens (human) | IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha |
| 3 | C (C) | Leukemia inhibitory factor receptor | polymer | 817 | 92834.8 | 1 | UniProt (P42702) Pfam (PF18207) Pfam (PF17971) Pfam (PF21177) Pfam (PF00041) | Homo sapiens (human) | LIF receptor,LIF-R |
| 4 | D, E, F (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G, H, I, J (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
B: 23 - 619 (UniProt: P40189)
C: 45 - 833 (UniProt: P42702)
| PDB | External Database | Details |
|---|---|---|
| Glu 620 | - | expression tag |
| Gln 621 | - | expression tag |
| Lys 622 | - | expression tag |
| Leu 623 | - | expression tag |
| Ile 624 | - | expression tag |
| Ser 625 | - | expression tag |
| Glu 626 | - | expression tag |
| Glu 627 | - | expression tag |
| Asp 628 | - | expression tag |
| Leu 629 | - | expression tag |
| Gly 630 | - | expression tag |
| Gly 631 | - | expression tag |
| Glu 632 | - | expression tag |
| Gln 633 | - | expression tag |
| Lys 634 | - | expression tag |
| Leu 635 | - | expression tag |
| Ile 636 | - | expression tag |
| Ser 637 | - | expression tag |
| Glu 638 | - | expression tag |
| Glu 639 | - | expression tag |
| Asp 640 | - | expression tag |
| Leu 641 | - | expression tag |
| His 642 | - | expression tag |
| His 643 | - | expression tag |
| His 644 | - | expression tag |
| His 645 | - | expression tag |
| His 646 | - | expression tag |
| His 647 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 834 | - | expression tag |
| Gln 835 | - | expression tag |
| Lys 836 | - | expression tag |
| Leu 837 | - | expression tag |
| Ile 838 | - | expression tag |
| Ser 839 | - | expression tag |
| Glu 840 | - | expression tag |
| Glu 841 | - | expression tag |
| Asp 842 | - | expression tag |
| Leu 843 | - | expression tag |
| Gly 844 | - | expression tag |
| Gly 845 | - | expression tag |
| Glu 846 | - | expression tag |
| Gln 847 | - | expression tag |
| Lys 848 | - | expression tag |
| Leu 849 | - | expression tag |
| Ile 850 | - | expression tag |
| Ser 851 | - | expression tag |
| Glu 852 | - | expression tag |
| Glu 853 | - | expression tag |
| Asp 854 | - | expression tag |
| Leu 855 | - | expression tag |
| His 856 | - | expression tag |
| His 857 | - | expression tag |
| His 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 186254.4 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 188412.4 |
