8V2A
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005147 | molecular_function | oncostatin-M receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006955 | biological_process | immune response |
| A | 0038165 | biological_process | oncostatin-M-mediated signaling pathway |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00590 |
| Number of Residues | 20 |
| Details | LIF_OSM LIF / OSM family signature. PasdaFQrKlegCrFLhgYH |
| Chain | Residue | Details |
| A | PRO180-HIS199 |
| site_id | PS01353 |
| Number of Residues | 51 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsvgsSppskiasmeipnddlkieqvvgmgkgil.......LtWhydPnmtcd....Yv.IkW |
| Chain | Residue | Details |
| C | ASN611-TRP661 | |
| B | ASN404-TRP457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 91 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
