8V2A
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005147 | molecular_function | oncostatin-M receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006955 | biological_process | immune response |
| A | 0038165 | biological_process | oncostatin-M-mediated signaling pathway |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00590 |
| Number of Residues | 20 |
| Details | LIF_OSM LIF / OSM family signature. PasdaFQrKlegCrFLhgYH |
| Chain | Residue | Details |
| A | PRO180-HIS199 |
| site_id | PS01353 |
| Number of Residues | 51 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsvgsSppskiasmeipnddlkieqvvgmgkgil.......LtWhydPnmtcd....Yv.IkW |
| Chain | Residue | Details |
| C | ASN611-TRP661 | |
| B | ASN404-TRP457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 788 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| C | GLN45-SER833 | |
| A | ASN217 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN64 | |
| C | ASN572 | |
| C | ASN652 | |
| C | ASN663 | |
| C | ASN680 | |
| C | ASN729 | |
| C | ASN787 | |
| C | ASN85 | |
| C | ASN143 | |
| C | ASN191 | |
| C | ASN243 | |
| C | ASN390 | |
| C | ASN445 | |
| C | ASN481 | |
| C | ASN489 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18775332 |
| Chain | Residue | Details |
| C | ASN131 | |
| C | ASN303 | |
| C | ASN407 | |
| C | ASN426 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211 |
| Chain | Residue | Details |
| B | ASN227 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| B | ASN379 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20489211 |
| Chain | Residue | Details |
| B | ASN383 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN390 |
