8UXM
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, H, I (I, J, L, K) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 2 | B, J, K, L (A, B, C, D) | Ryanodine receptor 2 | polymer | 4967 | 565315.1 | 4 | UniProt (Q92736) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) | Homo sapiens (human) | RYR-2,RyR2,hRYR-2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor |
| 3 | C, D, E, F (E, F, G, H) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 108 | 11798.5 | 4 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 4 | AA, BA, CA, DA, EA... (L, K, B, I, C...) | CALCIUM ION | non-polymer | 40.1 | 20 | Chemie (CA) | |||
| 5 | GA, KA, OA, Q (B, C, D, A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | HA, JA, LA, NA, PA... (B, C, D, A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (ATP) |
Sequence modifications
A, B, C, D: 1 - 4967 (UniProt: Q92736)
| PDB | External Database | Details |
|---|---|---|
| Trp 420 | Arg 420 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 2375864.7 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 5120.6 | |
| All* | Total formula weight | 2380985.3 |
