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8UXM

Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0002027biological_processregulation of heart rate
A0003143biological_processembryonic heart tube morphogenesis
A0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
A0003300biological_processcardiac muscle hypertrophy
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006941biological_processstriated muscle contraction
A0010460biological_processpositive regulation of heart rate
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
A0014701cellular_componentjunctional sarcoplasmic reticulum membrane
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0014850biological_processresponse to muscle activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0031000biological_processresponse to caffeine
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034704cellular_componentcalcium channel complex
A0035994biological_processresponse to muscle stretch
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043924molecular_functionsuramin binding
A0044325molecular_functiontransmembrane transporter binding
A0048763molecular_functioncalcium-induced calcium release activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051649biological_processestablishment of localization in cell
A0051775biological_processresponse to redox state
A0055085biological_processtransmembrane transport
A0055117biological_processregulation of cardiac muscle contraction
A0060048biological_processcardiac muscle contraction
A0060402biological_processcalcium ion transport into cytosol
A0070296biological_processsarcoplasmic reticulum calcium ion transport
A0070588biological_processcalcium ion transmembrane transport
A0071313biological_processcellular response to caffeine
A0071872biological_processcellular response to epinephrine stimulus
A0072599biological_processestablishment of protein localization to endoplasmic reticulum
A0086005biological_processventricular cardiac muscle cell action potential
A0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097050biological_processtype B pancreatic cell apoptotic process
A0097159molecular_functionorganic cyclic compound binding
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098735biological_processpositive regulation of the force of heart contraction
A0098904biological_processregulation of AV node cell action potential
A0098907biological_processregulation of SA node cell action potential
A0098910biological_processregulation of atrial cardiac muscle cell action potential
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0001666biological_processresponse to hypoxia
B0002027biological_processregulation of heart rate
B0003143biological_processembryonic heart tube morphogenesis
B0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
B0003300biological_processcardiac muscle hypertrophy
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006941biological_processstriated muscle contraction
B0010460biological_processpositive regulation of heart rate
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014701cellular_componentjunctional sarcoplasmic reticulum membrane
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014850biological_processresponse to muscle activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0031000biological_processresponse to caffeine
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034704cellular_componentcalcium channel complex
B0035994biological_processresponse to muscle stretch
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043924molecular_functionsuramin binding
B0044325molecular_functiontransmembrane transporter binding
B0048763molecular_functioncalcium-induced calcium release activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051284biological_processpositive regulation of sequestering of calcium ion
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051649biological_processestablishment of localization in cell
B0051775biological_processresponse to redox state
B0055085biological_processtransmembrane transport
B0055117biological_processregulation of cardiac muscle contraction
B0060048biological_processcardiac muscle contraction
B0060402biological_processcalcium ion transport into cytosol
B0070296biological_processsarcoplasmic reticulum calcium ion transport
B0070588biological_processcalcium ion transmembrane transport
B0071313biological_processcellular response to caffeine
B0071872biological_processcellular response to epinephrine stimulus
B0072599biological_processestablishment of protein localization to endoplasmic reticulum
B0086005biological_processventricular cardiac muscle cell action potential
B0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097050biological_processtype B pancreatic cell apoptotic process
B0097159molecular_functionorganic cyclic compound binding
B0097553biological_processcalcium ion transmembrane import into cytosol
B0098735biological_processpositive regulation of the force of heart contraction
B0098904biological_processregulation of AV node cell action potential
B0098907biological_processregulation of SA node cell action potential
B0098910biological_processregulation of atrial cardiac muscle cell action potential
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0001666biological_processresponse to hypoxia
C0002027biological_processregulation of heart rate
C0003143biological_processembryonic heart tube morphogenesis
C0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
C0003300biological_processcardiac muscle hypertrophy
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006941biological_processstriated muscle contraction
C0010460biological_processpositive regulation of heart rate
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
C0014701cellular_componentjunctional sarcoplasmic reticulum membrane
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0014850biological_processresponse to muscle activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0031000biological_processresponse to caffeine
C0032991cellular_componentprotein-containing complex
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034704cellular_componentcalcium channel complex
C0035994biological_processresponse to muscle stretch
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043924molecular_functionsuramin binding
C0044325molecular_functiontransmembrane transporter binding
C0048763molecular_functioncalcium-induced calcium release activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051284biological_processpositive regulation of sequestering of calcium ion
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051649biological_processestablishment of localization in cell
C0051775biological_processresponse to redox state
C0055085biological_processtransmembrane transport
C0055117biological_processregulation of cardiac muscle contraction
C0060048biological_processcardiac muscle contraction
C0060402biological_processcalcium ion transport into cytosol
C0070296biological_processsarcoplasmic reticulum calcium ion transport
C0070588biological_processcalcium ion transmembrane transport
C0071313biological_processcellular response to caffeine
C0071872biological_processcellular response to epinephrine stimulus
C0072599biological_processestablishment of protein localization to endoplasmic reticulum
C0086005biological_processventricular cardiac muscle cell action potential
C0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
C0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0097050biological_processtype B pancreatic cell apoptotic process
C0097159molecular_functionorganic cyclic compound binding
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098735biological_processpositive regulation of the force of heart contraction
C0098904biological_processregulation of AV node cell action potential
C0098907biological_processregulation of SA node cell action potential
C0098910biological_processregulation of atrial cardiac muscle cell action potential
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0001666biological_processresponse to hypoxia
D0002027biological_processregulation of heart rate
D0003143biological_processembryonic heart tube morphogenesis
D0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
D0003300biological_processcardiac muscle hypertrophy
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006941biological_processstriated muscle contraction
D0010460biological_processpositive regulation of heart rate
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
D0014701cellular_componentjunctional sarcoplasmic reticulum membrane
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014850biological_processresponse to muscle activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0031000biological_processresponse to caffeine
D0032991cellular_componentprotein-containing complex
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034704cellular_componentcalcium channel complex
D0035994biological_processresponse to muscle stretch
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043924molecular_functionsuramin binding
D0044325molecular_functiontransmembrane transporter binding
D0048763molecular_functioncalcium-induced calcium release activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051284biological_processpositive regulation of sequestering of calcium ion
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051649biological_processestablishment of localization in cell
D0051775biological_processresponse to redox state
D0055085biological_processtransmembrane transport
D0055117biological_processregulation of cardiac muscle contraction
D0060048biological_processcardiac muscle contraction
D0060402biological_processcalcium ion transport into cytosol
D0070296biological_processsarcoplasmic reticulum calcium ion transport
D0070588biological_processcalcium ion transmembrane transport
D0071313biological_processcellular response to caffeine
D0071872biological_processcellular response to epinephrine stimulus
D0072599biological_processestablishment of protein localization to endoplasmic reticulum
D0086005biological_processventricular cardiac muscle cell action potential
D0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
D0086064biological_processcell communication by electrical coupling involved in cardiac conduction
D0097050biological_processtype B pancreatic cell apoptotic process
D0097159molecular_functionorganic cyclic compound binding
D0097553biological_processcalcium ion transmembrane import into cytosol
D0098735biological_processpositive regulation of the force of heart contraction
D0098904biological_processregulation of AV node cell action potential
D0098907biological_processregulation of SA node cell action potential
D0098910biological_processregulation of atrial cardiac muscle cell action potential
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016247molecular_functionchannel regulator activity
E0016529cellular_componentsarcoplasmic reticulum
E0019227biological_processneuronal action potential propagation
E0019722biological_processcalcium-mediated signaling
E0019855molecular_functioncalcium channel inhibitor activity
E0022417biological_processprotein maturation by protein folding
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0030551molecular_functioncyclic nucleotide binding
E0033017cellular_componentsarcoplasmic reticulum membrane
E0033197biological_processresponse to vitamin E
E0034704cellular_componentcalcium channel complex
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0042542biological_processresponse to hydrogen peroxide
E0044325molecular_functiontransmembrane transporter binding
E0048680biological_processpositive regulation of axon regeneration
E0050849biological_processnegative regulation of calcium-mediated signaling
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051775biological_processresponse to redox state
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
F0002027biological_processregulation of heart rate
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005219molecular_functionryanodine-sensitive calcium-release channel activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0006458biological_process'de novo' protein folding
F0006939biological_processsmooth muscle contraction
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0009749biological_processresponse to glucose
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0016529cellular_componentsarcoplasmic reticulum
F0019227biological_processneuronal action potential propagation
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0022417biological_processprotein maturation by protein folding
F0030018cellular_componentZ disc
F0030073biological_processinsulin secretion
F0030551molecular_functioncyclic nucleotide binding
F0033017cellular_componentsarcoplasmic reticulum membrane
F0033197biological_processresponse to vitamin E
F0034704cellular_componentcalcium channel complex
F0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
F0042026biological_processprotein refolding
F0042098biological_processT cell proliferation
F0042542biological_processresponse to hydrogen peroxide
F0044325molecular_functiontransmembrane transporter binding
F0048680biological_processpositive regulation of axon regeneration
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051284biological_processpositive regulation of sequestering of calcium ion
F0051775biological_processresponse to redox state
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0016529cellular_componentsarcoplasmic reticulum
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0022417biological_processprotein maturation by protein folding
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0030551molecular_functioncyclic nucleotide binding
G0033017cellular_componentsarcoplasmic reticulum membrane
G0033197biological_processresponse to vitamin E
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0042542biological_processresponse to hydrogen peroxide
G0044325molecular_functiontransmembrane transporter binding
G0048680biological_processpositive regulation of axon regeneration
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051775biological_processresponse to redox state
G0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0016529cellular_componentsarcoplasmic reticulum
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0022417biological_processprotein maturation by protein folding
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0030551molecular_functioncyclic nucleotide binding
H0033017cellular_componentsarcoplasmic reticulum membrane
H0033197biological_processresponse to vitamin E
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0042542biological_processresponse to hydrogen peroxide
H0044325molecular_functiontransmembrane transporter binding
H0048680biological_processpositive regulation of axon regeneration
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051775biological_processresponse to redox state
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0007186biological_processG protein-coupled receptor signaling pathway
I0008076cellular_componentvoltage-gated potassium channel complex
I0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
I0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031954biological_processpositive regulation of protein autophosphorylation
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032516biological_processpositive regulation of phosphoprotein phosphatase activity
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035307biological_processpositive regulation of protein dephosphorylation
I0035458biological_processcellular response to interferon-beta
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044305cellular_componentcalyx of Held
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0098901biological_processregulation of cardiac muscle cell action potential
I0099523cellular_componentpresynaptic cytosol
I0140056biological_processorganelle localization by membrane tethering
I0140238biological_processpresynaptic endocytosis
I1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0000086biological_processG2/M transition of mitotic cell cycle
J0000922cellular_componentspindle pole
J0002027biological_processregulation of heart rate
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005876cellular_componentspindle microtubule
J0005886cellular_componentplasma membrane
J0007186biological_processG protein-coupled receptor signaling pathway
J0008076cellular_componentvoltage-gated potassium channel complex
J0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
J0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030017cellular_componentsarcomere
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031954biological_processpositive regulation of protein autophosphorylation
J0031982cellular_componentvesicle
J0032465biological_processregulation of cytokinesis
J0032516biological_processpositive regulation of phosphoprotein phosphatase activity
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035307biological_processpositive regulation of protein dephosphorylation
J0035458biological_processcellular response to interferon-beta
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0044305cellular_componentcalyx of Held
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050848biological_processregulation of calcium-mediated signaling
J0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
J0051592biological_processresponse to calcium ion
J0055117biological_processregulation of cardiac muscle contraction
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0071902biological_processpositive regulation of protein serine/threonine kinase activity
J0072542molecular_functionprotein phosphatase activator activity
J0097225cellular_componentsperm midpiece
J0098901biological_processregulation of cardiac muscle cell action potential
J0099523cellular_componentpresynaptic cytosol
J0140056biological_processorganelle localization by membrane tethering
J0140238biological_processpresynaptic endocytosis
J1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
J1901842biological_processnegative regulation of high voltage-gated calcium channel activity
J1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
J1902494cellular_componentcatalytic complex
J1905913biological_processnegative regulation of calcium ion export across plasma membrane
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0002027biological_processregulation of heart rate
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005886cellular_componentplasma membrane
K0007186biological_processG protein-coupled receptor signaling pathway
K0008076cellular_componentvoltage-gated potassium channel complex
K0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
K0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0021762biological_processsubstantia nigra development
K0030017cellular_componentsarcomere
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031954biological_processpositive regulation of protein autophosphorylation
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032516biological_processpositive regulation of phosphoprotein phosphatase activity
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035307biological_processpositive regulation of protein dephosphorylation
K0035458biological_processcellular response to interferon-beta
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0044305cellular_componentcalyx of Held
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0072542molecular_functionprotein phosphatase activator activity
K0097225cellular_componentsperm midpiece
K0098901biological_processregulation of cardiac muscle cell action potential
K0099523cellular_componentpresynaptic cytosol
K0140056biological_processorganelle localization by membrane tethering
K0140238biological_processpresynaptic endocytosis
K1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0007186biological_processG protein-coupled receptor signaling pathway
L0008076cellular_componentvoltage-gated potassium channel complex
L0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
L0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031954biological_processpositive regulation of protein autophosphorylation
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032516biological_processpositive regulation of phosphoprotein phosphatase activity
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035307biological_processpositive regulation of protein dephosphorylation
L0035458biological_processcellular response to interferon-beta
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044305cellular_componentcalyx of Held
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0098901biological_processregulation of cardiac muscle cell action potential
L0099523cellular_componentpresynaptic cytosol
L0140056biological_processorganelle localization by membrane tethering
L0140238biological_processpresynaptic endocytosis
L1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
IASP21-LEU33
IASP57-PHE69
IASP94-LEU106
IASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues17504
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-THR4281
IGLU68
JASP21
JASP23
JASP25
JTHR27
JGLU32
JASP57
JASP59
JASN61
JTHR63
AGLY4871-ASN4967
JGLU68
LASP21
LASP23
LASP25
LTHR27
LGLU32
LASP57
LASP59
LASN61
LTHR63
BMET1-THR4281
LGLU68
KASP21
KASP23
KASP25
KTHR27
KGLU32
KASP57
KASP59
KASN61
KTHR63
BGLY4871-ASN4967
KGLU68
CMET1-THR4281
CGLY4871-ASN4967
DMET1-THR4281
DGLY4871-ASN4967
ITHR63

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA4282-PHE4302
BVAL4730-PHE4750
BLEU4769-PHE4789
BPHE4850-PHE4870
CALA4282-PHE4302
CMET4504-THR4524
CTHR4580-PHE4600
CVAL4730-PHE4750
CLEU4769-PHE4789
CPHE4850-PHE4870
DALA4282-PHE4302
AMET4504-THR4524
DMET4504-THR4524
DTHR4580-PHE4600
DVAL4730-PHE4750
DLEU4769-PHE4789
DPHE4850-PHE4870
LGLU105
LASP130
LASP132
LASP134
LGLN136
ATHR4580-PHE4600
LGLU141
KASP94
KASP96
KASN98
KTYR100
KGLU105
KASP130
KASP132
KASP134
KGLN136
AVAL4730-PHE4750
KGLU141
ALEU4769-PHE4789
APHE4850-PHE4870
BALA4282-PHE4302
BMET4504-THR4524
BTHR4580-PHE4600

site_idSWS_FT_FI3
Number of Residues36
DetailsINTRAMEM: Pore-forming => ECO:0000250
ChainResidueDetails
AGLY4820-ASP4829
BGLY4820-ASP4829
CGLY4820-ASP4829
DGLY4820-ASP4829

site_idSWS_FT_FI4
Number of Residues20
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:E9Q401
ChainResidueDetails
ASER1341
BSER2947
CSER1341
CSER2369
CSER2797
CSER2811
CSER2947
DSER1341
DSER2369
DSER2797
DSER2811
ASER2369
DSER2947
ASER2797
ASER2811
ASER2947
BSER1341
BSER2369
BSER2797
BSER2811

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:B0LPN4
ChainResidueDetails
ASER1869
ASER2697
BSER1869
BSER2697
CSER1869
CSER2697
DSER1869
DSER2697

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:E9Q401
ChainResidueDetails
ASER2031
BSER2031
CSER2031
DSER2031

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:20056922
ChainResidueDetails
ASER2808
BSER2808
CSER2808
DSER2808

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000269|PubMed:20056922
ChainResidueDetails
ASER2814
BSER2814
CSER2814
DSER2814

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ISER102
JSER102
LSER102
KSER102

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ITHR111
JTHR111
LTHR111
KTHR111

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ILYS116
JLYS116
LLYS116
KLYS116

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ITYR139
JTYR139
LTYR139
KTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ILYS22
JLYS22
LLYS22
KLYS22

224572

PDB entries from 2024-09-04

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