8UWZ
The structure of Raamsizumab in complex with VEGF121
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (C, A) | Raamsizumab heavy chain | polymer | 228 | 24602.5 | 2 | Homo sapiens (human) | ||
| 2 | B, F (D, B) | Raamsizumab light chain S1C variant | polymer | 212 | 23379.0 | 2 | Homo sapiens (human) | ||
| 3 | C, D (E, F) | Isoform VEGF121 of Vascular endothelial growth factor A, long form | polymer | 121 | 14078.1 | 2 | UniProt (P15692) Pfam (PF00341) | Homo sapiens | |
| 4 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H (H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) |
Sequence modifications
E, F: 1 - 121 (UniProt: P15692)
| PDB | External Database | Details |
|---|---|---|
| Asn 115 | Lys 141 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 124119.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| All* | Total formula weight | 125130.0 |
