8UVO
Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Transitional endoplasmic reticulum ATPase | polymer | 806 | 89417.8 | 6 | UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP |
| 2 | G, H, J, K, M... (A, B, C, D, E...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 12 | Chemie (ADP) | |||
| 3 | I, L, O, R, U... (A, B, C, D, E...) | N-[3-(2,5-difluoro-4-{[(4M)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide | non-polymer | 513.6 | 6 | Chemie (XNU) |
Sequence modifications
A, B, C, D, E, F: 1 - 806 (UniProt: P55072)
| PDB | External Database | Details |
|---|---|---|
| His 155 | Arg 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 536506.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 8208.0 | |
| All* | Total formula weight | 544714.7 |
