8UVO

Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
A	VAL341-ARG359
A	VAL617-ARG635

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:20512113

Chain	Residue	Details
A	PRO247
D	PRO247
D	ASN348
D	HIS384
E	PRO247
E	ASN348
E	HIS384
F	PRO247
F	ASN348
F	HIS384
A	ASN348
A	HIS384
B	PRO247
B	ASN348
B	HIS384
C	PRO247
C	ASN348
C	HIS384

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	GLY521
B	GLY521
C	GLY521
D	GLY521
E	GLY521
F	GLY521

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER3
B	SER3
C	SER3
D	SER3
E	SER3
F	SER3

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER7
C	SER13
C	SER462
C	SER702
D	SER7
D	SER13
D	SER462
D	SER702
E	SER7
E	SER13
E	SER462
A	SER13
E	SER702
F	SER7
F	SER13
F	SER462
F	SER702
A	SER462
A	SER702
B	SER7
B	SER13
B	SER462
B	SER702
C	SER7

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER37
B	SER37
C	SER37
D	SER37
E	SER37
F	SER37

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634

Chain	Residue	Details
A	LYS315
B	LYS315
C	LYS315
D	LYS315
E	LYS315
F	LYS315

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	THR436
B	THR436
C	THR436
D	THR436
E	THR436
F	THR436

---

site_id	SWS_FT_FI9
Number of Residues	18
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	LYS502
D	LYS502
D	LYS505
D	LYS754
E	LYS502
E	LYS505
E	LYS754
F	LYS502
F	LYS505
F	LYS754
A	LYS505
A	LYS754
B	LYS502
B	LYS505
B	LYS754
C	LYS502
C	LYS505
C	LYS754

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	LYS668
B	LYS668
C	LYS668
D	LYS668
E	LYS668
F	LYS668

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER770
E	SER775
F	SER770
F	SER775
A	SER775
B	SER770
B	SER775
C	SER770
C	SER775
D	SER770
D	SER775
E	SER770

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	SER787
B	SER787
C	SER787
D	SER787
E	SER787
F	SER787

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	TYR805
B	TYR805
C	TYR805
D	TYR805
E	TYR805
F	TYR805

---

site_id	SWS_FT_FI14
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS8
D	LYS8
D	LYS18
E	LYS8
E	LYS18
F	LYS8
F	LYS18
A	LYS18
B	LYS8
B	LYS18
C	LYS8
C	LYS18

---