8UTB
Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562 fusion | polymer | 599 | 67220.8 | 5 | UniProt (P36544) UniProt (P0ABE7) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | Cytochrome b-562 |
| 2 | F, H, J, L, N (F, H, J, L, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | G, I, K, M, O (G, I, K, M, O) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 4 | AA, FA, KA, P, V (C, D, E, A, B) | N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea | non-polymer | 365.1 | 5 | Chemie (XG3) PubChem (310378) | |||
| 5 | BA, GA, LA, Q, W (C, D, E, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | CA, HA, MA, R, X (C, D, E, A, B) | EPIBATIDINE | non-polymer | 208.7 | 5 | Chemie (EPJ) PubChem (1204) PubChem (105084) PubChem (23844116) PubChem (443366) PubChem (44266825) PubChem (44297526) PubChem (44565060) PubChem (44592968) PubChem (854023) PubChem (53299320) PubChem (3073763) PubChem (6544477) PubChem (6604745) PubChem (6951099) PubChem (9859143) PubChem (10081807) PubChem (10176670) PubChem (11031065) PubChem (14976739) PubChem (14976740) PubChem (134963592) PubChem (163809006) | |||
| 7 | DA, IA, NA, S, Y (C, D, E, A, B) | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 5 | Chemie (9Z9) PubChem (134817783) | |||
| 8 | EA, JA, T, U, Z (D, E, A, B, C) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) PubChem (65167) PubChem (5497103) PubChem (6436017) PubChem (6506401) PubChem (168614) PubChem (10908846) PubChem (6070971) | |||
| 9 | OA, PA, QA, RA, SA (A, B, C, D, E) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 324 (UniProt: P36544)
A, B, C, D, E: 328 - 479 (UniProt: P36544)
A, B, C, D, E: 324 - 328 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 368 | deletion |
| - | Val 369 | deletion |
| - | Glu 370 | deletion |
| - | Met 371 | deletion |
| - | Ser 372 | deletion |
| - | Ala 373 | deletion |
| - | Val 374 | deletion |
| - | Ala 375 | deletion |
| - | Pro 376 | deletion |
| - | Pro 377 | deletion |
| - | Pro 378 | deletion |
| - | Ala 379 | deletion |
| - | Ser 380 | deletion |
| - | Asn 381 | deletion |
| - | Gly 382 | deletion |
| - | Asn 383 | deletion |
| - | Leu 384 | deletion |
| - | Leu 385 | deletion |
| - | Tyr 386 | deletion |
| - | Ile 387 | deletion |
| - | Gly 388 | deletion |
| - | Phe 389 | deletion |
| - | Arg 390 | deletion |
| - | Gly 391 | deletion |
| - | Leu 392 | deletion |
| - | Asp 393 | deletion |
| - | Gly 394 | deletion |
| - | Val 395 | deletion |
| - | His 396 | deletion |
| - | Cys 397 | deletion |
| - | Val 398 | deletion |
| - | Pro 399 | deletion |
| - | Thr 400 | deletion |
| - | Pro 401 | deletion |
| - | Asp 402 | deletion |
| - | Ser 403 | deletion |
| - | Gly 404 | deletion |
| - | Val 405 | deletion |
| - | Val 406 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ala 324 | - | linker |
| Gly 324 | - | linker |
| Ala 324 | - | linker |
| Met 324 | - | linker |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
| Gly 488 | - | linker |
| Gly 489 | - | linker |
| Gly 490 | - | linker |
| Ser 491 | - | linker |
| Gly 492 | - | linker |
| Gly 493 | - | linker |
| Gly 494 | - | linker |
| Ser 495 | - | linker |
| Gly 496 | - | linker |
| Gly 497 | - | linker |
| Ser 498 | - | linker |
| Ser 499 | - | linker |
| Ala 500 | - | linker |
| Trp 501 | - | expression tag |
| Ser 502 | - | expression tag |
| His 503 | - | expression tag |
| Pro 504 | - | expression tag |
| Gln 505 | - | expression tag |
| Phe 506 | - | expression tag |
| Glu 507 | - | expression tag |
| Lys 508 | - | expression tag |
| Gly 509 | - | linker |
| Ser 510 | - | linker |
| Gly 511 | - | linker |
| Glu 512 | - | linker |
| Gly 513 | - | linker |
| Arg 514 | - | linker |
| Gly 515 | - | linker |
| Ser 516 | - | linker |
| Leu 517 | - | linker |
| Leu 518 | - | linker |
| Thr 519 | - | linker |
| Cys 520 | - | linker |
| Gly 521 | - | linker |
| Asp 522 | - | linker |
| Val 523 | - | linker |
| Glu 524 | - | linker |
| Glu 525 | - | linker |
| Asn 526 | - | linker |
| Pro 527 | - | linker |
| Gly 528 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 324 | Met 29 | conflict |
| Ile 328 | His 124 | conflict |
| Leu 328 | Arg 128 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 336104.0 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5054.7 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 10499.6 | |
| All* | Total formula weight | 351658.3 |
