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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8UTB

Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005506molecular_functioniron ion binding
A0006811biological_processmonoatomic ion transport
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0022900biological_processelectron transport chain
A0034220biological_processmonoatomic ion transmembrane transport
A0042597cellular_componentperiplasmic space
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005506molecular_functioniron ion binding
B0006811biological_processmonoatomic ion transport
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0022900biological_processelectron transport chain
B0034220biological_processmonoatomic ion transmembrane transport
B0042597cellular_componentperiplasmic space
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005506molecular_functioniron ion binding
C0006811biological_processmonoatomic ion transport
C0009055molecular_functionelectron transfer activity
C0016020cellular_componentmembrane
C0020037molecular_functionheme binding
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0022900biological_processelectron transport chain
C0034220biological_processmonoatomic ion transmembrane transport
C0042597cellular_componentperiplasmic space
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005506molecular_functioniron ion binding
D0006811biological_processmonoatomic ion transport
D0009055molecular_functionelectron transfer activity
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0022900biological_processelectron transport chain
D0034220biological_processmonoatomic ion transmembrane transport
D0042597cellular_componentperiplasmic space
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005506molecular_functioniron ion binding
E0006811biological_processmonoatomic ion transport
E0009055molecular_functionelectron transfer activity
E0016020cellular_componentmembrane
E0020037molecular_functionheme binding
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0022900biological_processelectron transport chain
E0034220biological_processmonoatomic ion transmembrane transport
E0042597cellular_componentperiplasmic space
E0045211cellular_componentpostsynaptic membrane
E0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC
ChainResidueDetails
ACYS127-CYS141
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues315
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues35
DetailsRegion: {"description":"Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane","evidences":[{"source":"UniProtKB","id":"P49582","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues15
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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