8UQE

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E	polymer	461	50542.8	1	UniProt (Q8IYW5) UniProt (P61077) UniProt (Q16778) UniProt (P04908) Pfam (PF14447) Pfam (PF00179) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (human)

Sequence modifications

B: 1 - 94 (UniProt: Q8IYW5)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag
Ser 95	-	linker
Gly 96	-	linker
Ser 97	-	linker
Gly 98	-	linker
Ser 99	-	linker
Gly 100	-	linker
Ser 101	-	linker

B: 1002 - 1147 (UniProt: P61077)

PDB	External Database	Details
Arg 1022	Ser 22	engineered mutation
Lys 1085	Cys 85	engineered mutation
Gly 1148	-	linker
Ser 1149	-	linker
Gly 1150	-	linker
Ser 1151	-	linker
Gly 1152	-	linker
Ser 1153	-	linker
Gly 1154	-	linker
Gly 1155	-	linker
Ser 1156	-	linker
Gly 1157	-	linker
Gly 1158	-	linker
Gly 1159	-	linker
Ser 1160	-	linker
Gly 1161	-	linker
Gly 1162	-	linker
Ser 1163	-	linker
Gly 1164	-	linker
Gly 1165	-	linker
Ser 1166	-	linker
Gly 1167	-	linker
Gly 1168	-	linker
Ser 1169	-	linker
Gly 1170	-	linker
Ser 1171	-	linker
Gly 1172	-	linker
Ser 1173	-	linker

B: 2033 - 2123 (UniProt: Q16778)

PDB	External Database	Details
Ser 3011	-	linker

B: 3012 - 3105 (UniProt: P04908)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50542.8
All*	Total formula weight	50542.8

*Water molecules are not included.