8UQA
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (K) | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | polymer | 447 | 49523.9 | 1 | UniProt (Q8IYW5) UniProt (P61077) UniProt (Q16778) UniProt (P04908) Pfam (PF14447) Pfam (PF00179) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | |
| 2 | B, C, J (K) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 3 | D, E (K) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, H, I (K) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | K (K) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
K: 1 - 94 (UniProt: Q8IYW5)
K: 1002 - 1147 (UniProt: P61077)
K: 2033 - 2123 (UniProt: Q16778)
K: 3012 - 3105 (UniProt: P04908)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 95 | - | linker |
| Gly 96 | - | linker |
| Ser 97 | - | linker |
| Gly 98 | - | linker |
| Ser 99 | - | linker |
| Gly 100 | - | linker |
| Ser 101 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Lys 1085 | Cys 85 | engineered mutation |
| Gly 1148 | - | linker |
| Ser 1149 | - | linker |
| Gly 1150 | - | linker |
| Gly 1151 | - | linker |
| Ser 1152 | - | linker |
| Gly 1153 | - | linker |
| Gly 1154 | - | linker |
| Ser 1155 | - | linker |
| Gly 1156 | - | linker |
| Ser 1157 | - | linker |
| Gly 1158 | - | linker |
| Ser 1159 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 3011 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 49523.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 341.6 | |
| All* | Total formula weight | 49865.5 |
