8UPA
Structure of gp130 in complex with a de novo designed IL-6 mimetic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | De novo designed IL-6 mimetic | polymer | 56 | 6656.6 | 2 | synthetic construct | ||
| 2 | B, D (B, D) | Interleukin-6 receptor subunit beta | polymer | 203 | 23121.9 | 2 | UniProt (P40189) Pfam (PF09240) Pfam (PF00041) | Homo sapiens (human) | |
| 3 | E, F, H, I (B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | G (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | J (B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B, D: 124 - 321 (UniProt: P40189)
| PDB | External Database | Details |
|---|---|---|
| Asp 121 | - | expression tag |
| Gly 122 | - | expression tag |
| Ser 123 | - | expression tag |
| Ala 322 | - | expression tag |
| Ala 323 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59557.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 979.8 | |
| All* | Total formula weight | 60536.9 |
