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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8UPA

Structure of gp130 in complex with a de novo designed IL-6 mimetic

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues182
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsMotif: {"description":"WSXWS motif"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-06-17

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