8UKX
Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 7.0
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 357 | 39210.5 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF14843) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | B | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 268 - 273 (UniProt: P00533)
A: 274 - 618 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 273 | Val 30 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 283 | Cys 307 | engineered mutation |
His 619 | - | expression tag |
His 620 | - | expression tag |
His 621 | - | expression tag |
His 622 | - | expression tag |
His 623 | - | expression tag |
His 624 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 39210.5 | |
Branched | Number of molecules | 1 |
Total formula weight | 367.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 40020.2 |