8UKW
Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 5.0
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Epidermal growth factor receptor | polymer | 357 | 39210.5 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF14843) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
3 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B: 268 - 273 (UniProt: P00533)
A, B: 274 - 618 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 273 | Val 30 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 283 | Cys 307 | engineered mutation |
His 619 | - | expression tag |
His 620 | - | expression tag |
His 621 | - | expression tag |
His 622 | - | expression tag |
His 623 | - | expression tag |
His 624 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 78420.9 | |
Branched | Number of molecules | 3 |
Total formula weight | 1435.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 80741.1 |