8UHG
Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | X | Negative elongation factor E | polymer | 380 | 43320.9 | 1 | UniProt (P18615) Pfam (PF00076) In PDB | Homo sapiens (human) | NELF-E,RNA-binding protein RD |
2 | V | Negative elongation factor B | polymer | 554 | 63233.3 | 1 | UniProt (Q8WX92) Pfam (PF06209) In PDB | Homo sapiens (human) | NELF-B,Cofactor of BRCA1 |
3 | W | Negative elongation factor C/D | polymer | 590 | 66315.4 | 1 | UniProt (Q8IXH7) Pfam (PF04858) In PDB | Homo sapiens (human) | NELF-C/D,TH1-like protein |
4 | A | DNA-directed RNA polymerase subunit | polymer | 1970 | 217450.1 | 1 | UniProt (A0A8D1DPV6) Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) In PDB | Sus scrofa (pig) | |
5 | B | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (A0A4X1TVZ5) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) UniProt (by SIFTS) (I3LGP4) In PDB | Sus scrofa (pig) | |
6 | C | DNA-directed RNA polymerase II subunit RPB3 | polymer | 271 | 30997.6 | 1 | UniProt (A0A481DF93) Pfam (PF01193) Pfam (PF01000) UniProt (by SIFTS) (I3LCH3) In PDB | Sus scrofa (pig) | |
7 | D | RNA polymerase Rpb4/RPC9 core domain-containing protein | polymer | 142 | 16331.3 | 1 | UniProt (A0A8D0KES4) Pfam (PF03874) UniProt (by SIFTS) (A0A4X1VM56) In PDB | Sus scrofa (pig) | |
8 | E | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (A0A4X1VTX4) Pfam (PF03871) Pfam (PF01191) UniProt (by SIFTS) (I3LSI7) In PDB | Sus scrofa (pig) | RPB5 |
9 | F | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14477.0 | 1 | UniProt (A0A4X1VEK9) Pfam (PF01192) In PDB | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit F,RPB6 homolog |
10 | G | DNA-directed RNA polymerase subunit | polymer | 171 | 19227.2 | 1 | UniProt (A0A4X1VKG7) Pfam (PF03876) Pfam (PF00575) In PDB | Sus scrofa (pig) | |
11 | H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (A0A8D1AQR7) Pfam (PF03870) UniProt (by SIFTS) (I3LCB2) In PDB | Sus scrofa (pig) | |
12 | I | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) In PDB | Sus scrofa (pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
13 | J | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A8W4F9W9) Pfam (PF01194) In PDB | Sus scrofa (pig) | |
14 | K | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 115 | 13068.0 | 1 | UniProt (F1RKE4) Pfam (PF13656) In PDB | Sus scrofa (pig) | |
15 | L | RNA polymerase II subunit K | polymer | 58 | 7018.2 | 1 | UniProt (A0A4X1TRS6) Pfam (PF03604) In PDB | Sus scrofa (pig) | |
16 | N | Non-template DNA | polymer | 50 | 15409.9 | 1 | synthetic construct | ||
17 | P | RNA | polymer | 16 | 5077.0 | 1 | synthetic construct | ||
18 | T | Template DNA | polymer | 38 | 11728.6 | 1 | synthetic construct | ||
19 | U | Negative elongation factor A | polymer | 528 | 57343.6 | 1 | UniProt (Q9H3P2) In PDB | Homo sapiens (human) | NELF-A,Wolf-Hirschhorn syndrome candidate 2 protein |
20 | Z | Transcription elongation factor SPT5 | polymer | 1087 | 121145.5 | 1 | UniProt (O00267) Pfam (PF11942) Pfam (PF03439) Pfam (PF00467) In PDB | Homo sapiens (human) | hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein |
21 | I, J, L, A, B... | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
22 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 20 |
Total formula weight | 900187.7 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 547.6 | |
All* | Total formula weight | 900735.3 |