8UHB
Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Soluble cytochrome b562,Beta-2 adrenergic receptor,Trace amine-associated receptor 1 | polymer | 524 | 60019.8 | 1 | UniProt (P0ABE7) UniProt (P07550) UniProt (Q96RJ0) Pfam (PF07361) Pfam (PF00001) In PDB | Homo sapiens (human) | Cytochrome b-562 |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45803.6 | 1 | UniProt (P63095) Pfam (PF00503) In PDB | Rattus norvegicus (Norway rat) | |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | N | Nanobody 35 | polymer | 134 | 14714.3 | 1 | Lama glama | ||
6 | A | (2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine | non-polymer | 218.3 | 1 | Chemie (WV8) |
Sequence modifications
A: -135 - -35 (UniProt: P0ABE7)
A: -29 - 0 (UniProt: P07550)
A: 1 - 339 (UniProt: Q96RJ0)
B: 7 - 340 (UniProt: P62873)
C: 1 - 394 (UniProt: P63095)
PDB | External Database | Details |
---|---|---|
Met -184 | - | expression tag |
Lys -183 | - | expression tag |
Thr -182 | - | expression tag |
Ile -181 | - | expression tag |
Ile -180 | - | expression tag |
Ala -179 | - | expression tag |
Leu -178 | - | expression tag |
Ser -177 | - | expression tag |
Tyr -176 | - | expression tag |
Ile -175 | - | expression tag |
Phe -174 | - | expression tag |
Cys -173 | - | expression tag |
Leu -172 | - | expression tag |
Val -171 | - | expression tag |
Phe -170 | - | expression tag |
Ala -169 | - | expression tag |
Asp -168 | - | expression tag |
Tyr -167 | - | expression tag |
Lys -166 | - | expression tag |
Asp -165 | - | expression tag |
Asp -164 | - | expression tag |
Asp -163 | - | expression tag |
Asp -162 | - | expression tag |
Ala -161 | - | expression tag |
Lys -160 | - | expression tag |
Leu -159 | - | expression tag |
Gln -158 | - | expression tag |
Thr -157 | - | expression tag |
Met -156 | - | expression tag |
His -155 | - | expression tag |
His -154 | - | expression tag |
His -153 | - | expression tag |
His -152 | - | expression tag |
His -151 | - | expression tag |
His -150 | - | expression tag |
His -149 | - | expression tag |
His -148 | - | expression tag |
His -147 | - | expression tag |
His -146 | - | expression tag |
Glu -145 | - | expression tag |
Asn -144 | - | expression tag |
Leu -143 | - | expression tag |
Tyr -142 | - | expression tag |
Phe -141 | - | expression tag |
Gln -140 | - | expression tag |
Gly -139 | - | expression tag |
Gly -138 | - | expression tag |
Thr -137 | - | expression tag |
Thr -136 | - | expression tag |
Trp -129 | Met 29 | engineered mutation |
Ile -34 | - | linker |
Gln -33 | - | linker |
Lys -32 | - | linker |
Tyr -31 | - | linker |
Leu -30 | - | linker |
PDB | External Database | Details |
---|---|---|
Arg -14 | Gly 16 | variant |
Gln -3 | Glu 27 | variant |
PDB | External Database | Details |
---|---|---|
Trp 112 | Phe 112 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Glu 3 | - | expression tag |
Leu 4 | - | expression tag |
Asp 5 | - | expression tag |
Gln 6 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 189 | Asp 189 | engineered mutation |
Met 191 | Val 191 | engineered mutation |
Thr 193 | Ser 193 | engineered mutation |
Glu 194 | Asp 194 | engineered mutation |
Ala 226 | Gly 226 | engineered mutation |
Lys 271 | Asn 271 | engineered mutation |
Asp 274 | Lys 274 | engineered mutation |
Lys 280 | Arg 280 | engineered mutation |
Asp 284 | Thr 284 | engineered mutation |
Thr 285 | Ile 285 | engineered mutation |
Ser 366 | Ala 366 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 167817.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 218.3 | |
All* | Total formula weight | 168035.3 |