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8UHB

Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001594molecular_functiontrace-amine receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0005506molecular_functioniron ion binding
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0008227molecular_functionG protein-coupled amine receptor activity
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0042597cellular_componentperiplasmic space
A0046872molecular_functionmetal ion binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0001501biological_processskeletal system development
C0001726cellular_componentruffle
C0001894biological_processtissue homeostasis
C0001934biological_processpositive regulation of protein phosphorylation
C0001958biological_processendochondral ossification
C0001965molecular_functionG-protein alpha-subunit binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0006112biological_processenergy reserve metabolic process
C0006357biological_processregulation of transcription by RNA polymerase II
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007606biological_processsensory perception of chemical stimulus
C0008284biological_processpositive regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009791biological_processpost-embryonic development
C0009966biological_processregulation of signal transduction
C0010765biological_processpositive regulation of sodium ion transport
C0010854molecular_functionadenylate cyclase regulator activity
C0010856molecular_functionadenylate cyclase activator activity
C0016020cellular_componentmembrane
C0019001molecular_functionguanyl nucleotide binding
C0019904molecular_functionprotein domain specific binding
C0030142cellular_componentCOPI-coated Golgi to ER transport vesicle
C0030425cellular_componentdendrite
C0031681molecular_functionG-protein beta-subunit binding
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031698molecular_functionbeta-2 adrenergic receptor binding
C0031748molecular_functionD1 dopamine receptor binding
C0031852molecular_functionmu-type opioid receptor binding
C0032024biological_processpositive regulation of insulin secretion
C0032588cellular_componenttrans-Golgi network membrane
C0035116biological_processembryonic hindlimb morphogenesis
C0035255molecular_functionionotropic glutamate receptor binding
C0035264biological_processmulticellular organism growth
C0040015biological_processnegative regulation of multicellular organism growth
C0040032biological_processpost-embryonic body morphogenesis
C0042383cellular_componentsarcolemma
C0043014molecular_functionalpha-tubulin binding
C0043025cellular_componentneuronal cell body
C0043588biological_processskin development
C0045669biological_processpositive regulation of osteoblast differentiation
C0045672biological_processpositive regulation of osteoclast differentiation
C0045776biological_processnegative regulation of blood pressure
C0046872molecular_functionmetal ion binding
C0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
C0048471cellular_componentperinuclear region of cytoplasm
C0048589biological_processdevelopmental growth
C0048701biological_processembryonic cranial skeleton morphogenesis
C0050890biological_processcognition
C0051216biological_processcartilage development
C0051430molecular_functioncorticotropin-releasing hormone receptor 1 binding
C0055037cellular_componentrecycling endosome
C0060348biological_processbone development
C0060789biological_processhair follicle placode formation
C0070527biological_processplatelet aggregation
C0071107biological_processresponse to parathyroid hormone
C0071377biological_processcellular response to glucagon stimulus
C0071380biological_processcellular response to prostaglandin E stimulus
C0071514biological_processgenomic imprinting
C0071870biological_processcellular response to catecholamine stimulus
C0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
C0120162biological_processpositive regulation of cold-induced thermogenesis
C2000828biological_processregulation of parathyroid hormone secretion
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLSFISIDRYYaV
ChainResidueDetails
AALA109-VAL125

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2
CSER54
CLEU197
CTHR204
CASP223
CASN292
CSER366

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
AASN-15

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
AMET81-ILE98
AMET158-LYS188
AASP274-ASP287

site_idSWS_FT_FI4
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:8347607
ChainResidueDetails
CCYS3

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092
ChainResidueDetails
CLYS300
AASP120-ASN136
ATYR210-THR252
APRO309-SER339

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ATRP60-SER80

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AHIS99-ILE119

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AILE137-GLY157

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AILE189-VAL209

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ALEU253-MET273

site_idSWS_FT_FI11
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AVAL288-TYR308

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN10
AASN17

222415

PDB entries from 2024-07-10

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