8UDV
The X-RAY co-crystal structure of human FGFR3 V555M and Compound 17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fibroblast growth factor receptor 3 | polymer | 297 | 33774.1 | 3 | UniProt (P22607) Pfam (PF07714) | Homo sapiens (human) | FGFR-3 |
| 2 | D, E, G, H, I... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | F, J, N (A, B, C) | 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide | non-polymer | 524.0 | 3 | Chemie (WIQ) | |||
| 4 | M (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | O, P, Q (A, B, C) | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
A, B, C: 455 - 756 (UniProt: P22607)
| PDB | External Database | Details |
|---|---|---|
| Met 454 | - | initiating methionine |
| Met 555 | Val 555 | engineered mutation |
| - | Pro 572 | deletion |
| - | Pro 573 | deletion |
| - | Gly 574 | deletion |
| - | Leu 575 | deletion |
| - | Asp 576 | deletion |
| - | Tyr 577 | deletion |
| - | Ser 578 | deletion |
| - | Phe 579 | deletion |
| - | Asp 580 | deletion |
| - | Thr 581 | deletion |
| - | Cys 582 | deletion |
| - | Lys 583 | deletion |
| Ser 572 | Pro 584 | conflict |
| Gly 573 | Pro 585 | conflict |
| His 757 | - | expression tag |
| His 758 | - | expression tag |
| His 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| His 762 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 101322.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2306.6 | |
| All* | Total formula weight | 103628.8 |
