8UCA
Formation of I2+III2 supercomplex rescues respiratory chain defects
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, OA (3, 3a) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13223.8 | 2 | UniProt (P03899) Pfam (PF00507) | Mus musculus (house mouse) | |
| 2 | B, PA (S3, s3) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 263 | 30191.3 | 2 | UniProt (Q9DCT2) Pfam (PF00329) | Mus musculus (house mouse) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 3 | C, QA (S2, s2) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52720.6 | 2 | UniProt (Q91WD5) Pfam (PF00346) | Mus musculus (house mouse) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 4 | D, RA (1, 1a) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 36105.0 | 2 | UniProt (Q4JFN6) Pfam (PF00146) | Mus musculus (house mouse) | |
| 5 | E, SA (6, 6a) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 172 | 18628.1 | 2 | UniProt (P03925) Pfam (PF00499) | Mus musculus (house mouse) | NADH dehydrogenase subunit 6 |
| 6 | F, TA (4L, 4l) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10609.6 | 2 | UniProt (P03903) Pfam (PF00420) | Mus musculus (house mouse) | NADH dehydrogenase subunit 4L |
| 7 | G, UA (5, 5a) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 607 | 68519.3 | 2 | UniProt (P03921) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Mus musculus (house mouse) | NADH dehydrogenase subunit 5 |
| 8 | H, VA (4, 4a) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51915.5 | 2 | UniProt (P03911) Pfam (PF01059) Pfam (PF00361) | Mus musculus (house mouse) | NADH dehydrogenase subunit 4 |
| 9 | I, WA (2, 2a) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 345 | 38772.2 | 2 | UniProt (P03893) Pfam (PF00361) Pfam (PF06444) | Mus musculus (house mouse) | NADH dehydrogenase subunit 2 |
| 10 | J, XA (AL, al) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 355 | 40657.4 | 2 | UniProt (Q99LC3) Pfam (PF01712) | Mus musculus (house mouse) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 11 | K, YA (A9, a9) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42588.1 | 2 | UniProt (Q9DC69) Pfam (PF05368) | Mus musculus (house mouse) | |
| 12 | L, ZA (S4, s4) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19814.7 | 2 | UniProt (Q9CXZ1) Pfam (PF04800) | Mus musculus (house mouse) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 13 | AB, M (S6, s6) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 116 | 13041.8 | 2 | UniProt (P52503) Pfam (PF10276) | Mus musculus (house mouse) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 14 | BB, N (A2, a2) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 10932.7 | 2 | UniProt (Q9CQ75) Pfam (PF05047) | Mus musculus (house mouse) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 15 | CB, DB, O, P (AB, AC, ab, ac) | Acyl carrier protein, mitochondrial | polymer | 156 | 17390.3 | 4 | UniProt (Q9CR21) Pfam (PF00550) | Mus musculus (house mouse) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 16 | EB, Q (A5, a5) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13380.7 | 2 | UniProt (Q9CPP6) Pfam (PF04716) | Mus musculus (house mouse) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 17 | FB, R (A6, a6) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 131 | 15311.9 | 2 | UniProt (Q9CQZ5) Pfam (PF13233) | Mus musculus (house mouse) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 18 | GB, S (A8, a8) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20025.1 | 2 | UniProt (Q9DCJ5) Pfam (PF06747) | Mus musculus (house mouse) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 19 | HB, T (AM, am) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 142 | 14999.2 | 2 | UniProt (G5E814) Pfam (PF02466) | Mus musculus (house mouse) | |
| 20 | IB, U (AO, ao) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16881.6 | 2 | UniProt (Q9ERS2) Pfam (PF06212) | Mus musculus (house mouse) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,GRIM-19,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 21 | JB, V (A1, a1) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8149.5 | 2 | UniProt (O35683) Pfam (PF15879) | Mus musculus (house mouse) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 22 | KB, W (A3, a3) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9338.9 | 2 | UniProt (Q9CQ91) Pfam (PF14987) | Mus musculus (house mouse) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 23 | LB, X (C1, c1) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8636.0 | 2 | UniProt (Q9CQY9) Pfam (PF15088) | Mus musculus (house mouse) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 24 | MB, Y (C2, c2) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14185.7 | 2 | UniProt (Q9CQ54) Pfam (PF06374) | Mus musculus (house mouse) | |
| 25 | NB, Z (S5, s5) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12675.8 | 2 | UniProt (Q99LY9) Pfam (PF10200) | Mus musculus (house mouse) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 26 | AA, OB (B1, b1) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6965.1 | 2 | UniProt (P0DN34) Pfam (PF08040) | Mus musculus (house mouse) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 27 | BA, PB (BM, bm) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 151 | 17463.7 | 2 | UniProt (O09111) Pfam (PF10183) | Mus musculus (house mouse) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 15.6,Np15.6,p15.6 |
| 28 | CA, QB (B5, b5) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21742.2 | 2 | UniProt (Q9CQH3) Pfam (PF09781) | Mus musculus (house mouse) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 29 | DA, RB (B6, b6) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 127 | 15408.9 | 2 | UniProt (Q3UIU2) Pfam (PF09782) | Mus musculus (house mouse) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 30 | EA, SB (B2, b2) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11982.4 | 2 | UniProt (Q9CPU2) Pfam (PF14813) | Mus musculus (house mouse) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 31 | FA, TB (B3, b3) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 104 | 11714.2 | 2 | UniProt (Q9CQZ6) Pfam (PF08122) | Mus musculus (house mouse) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 32 | GA, UB (B8, b8) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21903.8 | 2 | UniProt (Q9D6J5) Pfam (PF05821) | Mus musculus (house mouse) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 33 | HA, VB (B4, b4) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15105.3 | 2 | UniProt (Q9CQC7) Pfam (PF07225) | Mus musculus (house mouse) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 34 | IA, WB (B9, b9) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 22020.1 | 2 | UniProt (Q9CQJ8) Pfam (PF05347) | Mus musculus (house mouse) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 35 | JA, XB (B7, b7) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 136 | 16229.6 | 2 | UniProt (Q9CR61) Pfam (PF05676) | Mus musculus (house mouse) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 36 | KA, YB (BL, bl) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21054.8 | 2 | UniProt (Q9DCS9) Pfam (PF10249) | Mus musculus (house mouse) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 37 | LA, ZB (AN, an) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17112.4 | 2 | UniProt (Q7TMF3) Pfam (PF05071) | Mus musculus (house mouse) | Complex I-B17.2,CI-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 38 | AC, MA (A7, a7) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 112 | 12464.4 | 2 | UniProt (Q9Z1P6) Pfam (PF07347) | Mus musculus (house mouse) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 39 | BC, NA (V3, v3) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 104 | 11833.5 | 2 | UniProt (Q8BK30) Pfam (PF15880) | Mus musculus (house mouse) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 40 | CC, MC (3A, 3L) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 446 | 49355.3 | 2 | UniProt (Q9CZ13) Pfam (PF00675) Pfam (PF05193) | Mus musculus (house mouse) | |
| 41 | DC, NC (3B, 3M) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 439 | 46641.8 | 2 | UniProt (Q9DB77) Pfam (PF00675) Pfam (PF05193) | Mus musculus (house mouse) | |
| 42 | EC, OC (3C, 3N) | Cytochrome b | polymer | 380 | 43143.2 | 2 | UniProt (P00158) Pfam (PF00032) Pfam (PF00033) | Mus musculus (house mouse) | |
| 43 | FC, PC (3D, 3O) | Cytochrome c1, heme protein, mitochondrial | polymer | 241 | 27312.2 | 2 | UniProt (Q9D0M3) Pfam (PF02167) | Mus musculus (house mouse) | |
| 44 | GC, QC (3E, 3P) | Cytochrome b-c1 complex subunit 9 | polymer | 196 | 21524.4 | 2 | UniProt (Q9CR68) Pfam (PF02921) Pfam (PF00355) | Mus musculus (house mouse) | Su9,Subunit 9,8 kDa subunit 9,Complex III subunit IX,Cytochrome b-c1 complex subunit 11,UQCRFS1 mitochondrial targeting sequence,UQCRFS1 MTS,Ubiquinol-cytochrome c reductase 8 kDa protein |
| 45 | HC, RC (3F, 3Q) | Cytochrome b-c1 complex subunit 7 | polymer | 110 | 13456.3 | 2 | UniProt (Q9CQB4) Pfam (PF02271) | Mus musculus (house mouse) | |
| 46 | IC, SC (3G, 3R) | Cytochrome b-c1 complex subunit 8 | polymer | 81 | 9652.1 | 2 | UniProt (Q9CQ69) Pfam (PF02939) | Mus musculus (house mouse) | Complex III subunit 8,Complex III subunit VIII,Ubiquinol-cytochrome c reductase complex 9.5 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
| 47 | JC, TC (3H, 3S) | Cytochrome b-c1 complex subunit 6, mitochondrial | polymer | 76 | 9002.0 | 2 | UniProt (P99028) Pfam (PF02320) | Mus musculus (house mouse) | Complex III subunit 6,Complex III subunit VIII,Cytochrome c1 non-heme 11 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 11 kDa protein |
| 48 | KC, VC (3J, 3U) | Cytochrome b-c1 complex subunit 9 | polymer | 63 | 7326.3 | 2 | UniProt (Q8R1I1) Pfam (PF05365) | Mus musculus (house mouse) | Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7 kDa protein,Ubiquinol-cytochrome c reductase complex 7.2 kDa protein |
| 49 | LC, WC (3K, 3V) | Cytochrome b-c1 complex subunit 10 | polymer | 56 | 6546.6 | 2 | UniProt (Q9CPX8) Pfam (PF08997) | Mus musculus (house mouse) | Complex III subunit 10,Complex III subunit XI,Ubiquinol-cytochrome c reductase complex 6.4 kDa protein |
| 50 | UC (3T) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 78 | 7900.2 | 1 | UniProt (Q9CR68) Pfam (PF09165) | Mus musculus (house mouse) | |
| 51 | CD, XC (V1, v1) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 457 | 50132.3 | 2 | UniProt (Q91YT0) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Mus musculus (house mouse) | Complex I-51kD,CI-51kD,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 52 | DD, YC (V2, v2) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 244 | 26948.9 | 2 | UniProt (Q9D6J6) Pfam (PF01257) | Mus musculus (house mouse) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 53 | ED, ZC (S1, s1) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 716 | 78781.5 | 2 | UniProt (Q91VD9) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) | Mus musculus (house mouse) | Complex I-75kD,CI-75kD |
| 54 | AD, FD (S7, s7) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 224 | 24715.9 | 2 | UniProt (Q9DC70) Pfam (PF01058) | Mus musculus (house mouse) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 55 | BD, GD (S8, s8) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 24068.4 | 2 | UniProt (Q8K3J1) Pfam (PF12838) | Mus musculus (house mouse) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 56 | HD, OD (AL, al) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 57 | ID, PD (AL, al) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (DGT) | |||
| 58 | JD, QD (A9, a9) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 59 | KD, RD (S6, s6) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 60 | LD, MD, ND, SD (A6, B9, 5a, a6) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 4 | Chemie (EHZ) | |||
| 61 | TD, UD, WD, XD (3C, 3N) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 62 | VD, YD (3D, 3O) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 63 | IE, ZD (v1, V1) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
| 64 | AE, CE, DE, FE, GE... (V1, S1, S7, S8, v1...) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 12 | Chemie (SF4) | |||
| 65 | BE, EE, KE, NE (V2, S1, v2, s1) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 111 |
| Total formula weight | 2563286.1 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 14562.0 | |
| All* | Total formula weight | 2577848.2 |
