8U7M
Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inosine-5'-monophosphate dehydrogenase 1 | polymer | 597 | 63579.4 | 8 | UniProt (P20839) Pfam (PF00478) Pfam (PF00571) | Homo sapiens (human) | |
| 2 | CA, DA, HA, I, IA... (E, F, A, G, B...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) | |||
| 3 | EA, JA, K, OA, P... (E, F, A, G, B...) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (ATP) | |||
| 4 | AA, FA, KA, L, PA... (D, E, F, A, G...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
| 5 | BA, GA, LA, M, QA... (D, E, F, A, G...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, B, C, D, E, F, G, H: -48 - 509 (UniProt: P20839)
| PDB | External Database | Details |
|---|---|---|
| Gly -50 | - | expression tag |
| Ser -49 | - | expression tag |
| Asp 477 | Ser 526 | engineered mutation |
| Thr 510 | - | variant |
| Phe 511 | - | variant |
| Leu 512 | - | variant |
| Pro 513 | - | variant |
| Phe 514 | - | variant |
| Thr 515 | - | variant |
| Lys 516 | - | variant |
| Ser 517 | - | variant |
| Gly 518 | - | variant |
| Cys 519 | - | variant |
| Thr 520 | - | variant |
| Glu 521 | - | variant |
| Asp 522 | - | variant |
| Ser 523 | - | variant |
| Gly 524 | - | variant |
| Gly 525 | - | variant |
| Gly 526 | - | variant |
| Arg 527 | - | variant |
| Gly 528 | - | variant |
| Gly 529 | - | variant |
| Gly 530 | - | variant |
| Gly 531 | - | variant |
| Asp 532 | - | variant |
| Ala 533 | - | variant |
| Pro 534 | - | variant |
| Gln 535 | - | variant |
| Cys 536 | - | variant |
| Pro 537 | - | variant |
| Leu 538 | - | variant |
| Leu 539 | - | variant |
| Gly 540 | - | variant |
| Thr 541 | - | variant |
| Ala 542 | - | variant |
| Ser 543 | - | variant |
| Leu 544 | - | variant |
| His 545 | - | variant |
| Asn 546 | - | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 508635.6 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 20521.4 | |
| All* | Total formula weight | 529157.0 |
