8U5G

Crystal structure of the co-expressed SDS22:PP1:I3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	299	34162.1	1	UniProt (P62136) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (human)	PP-1A
2	B (B)	Protein phosphatase 1 regulatory subunit 7	polymer	310	36087.3	1	UniProt (Q15435) Pfam (PF12799) Pfam (PF14580)	Homo sapiens (human)	Protein phosphatase 1 regulatory subunit 22
3	C (C)	E3 ubiquitin-protein ligase PPP1R11	polymer	46	5367.3	1	UniProt (O60927) Pfam (PF07491)	Homo sapiens (human)	Hemochromatosis candidate gene V protein,HCG V,Protein phosphatase 1 regulatory subunit 11,Protein phosphatase inhibitor 3
4	D (A)	FE (III) ION	non-polymer		55.8	1	Chemie (FE)
5	E, F, G, H, I... (A, B)	PHOSPHATE ION	non-polymer		95.0	10	Chemie (PO4)
6	O, P, Q (A, B, C)	water	water		18.0	44	Chemie (HOH)

Sequence modifications

A: 7 - 300 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

B: 56 - 360 (UniProt: Q15435)

PDB	External Database	Details
Gly 51	-	expression tag
His 52	-	expression tag
Met 53	-	expression tag
Gly 54	-	expression tag
Ser 55	-	expression tag

C: 27 - 68 (UniProt: O60927)

PDB	External Database	Details
Gly 23	-	expression tag
Ala 24	-	expression tag
Met 25	-	expression tag
Gly 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	75616.7
Non-Polymers*	Number of molecules	11
	Total formula weight	1005.6
All*	Total formula weight	76622.3

*Water molecules are not included.