8U5C

The mTORC1 cholesterol sensor LYCHOS (GPR155) with cholesterol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (E, F)	Integral membrane protein GPR155	polymer	890	99171.8	2	UniProt (Q7Z3F1) Pfam (PF03547) Pfam (PF00610)	Homo sapiens (human)
2	C, D, E, F (E, F)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	4	Chemie (Y01)

Sequence modifications

E, F: 1 - 870 (UniProt: Q7Z3F1)

PDB	External Database	Details
Ala 352	Phe 352	conflict
Arg 678	Trp 678	conflict
Gly 871	-	expression tag
Ser 872	-	expression tag
Gly 873	-	expression tag
Ser 874	-	expression tag
Asp 875	-	expression tag
Tyr 876	-	expression tag
Lys 877	-	expression tag
Asp 878	-	expression tag
Asp 879	-	expression tag
Asp 880	-	expression tag
Asp 881	-	expression tag
Lys 882	-	expression tag
Asp 883	-	expression tag
Tyr 884	-	expression tag
Lys 885	-	expression tag
Asp 886	-	expression tag
Asp 887	-	expression tag
Asp 888	-	expression tag
Asp 889	-	expression tag
Lys 890	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	198343.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1946.9
All*	Total formula weight	200290.5

*Water molecules are not included.