Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U5C

The mTORC1 cholesterol sensor LYCHOS (GPR155) with cholesterol

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0002181	biological_process	cytoplasmic translation
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0008289	molecular_function	lipid binding
E	0015485	molecular_function	cholesterol binding
E	0016020	cellular_component	membrane
E	0030514	biological_process	negative regulation of BMP signaling pathway
E	0031503	biological_process	protein-containing complex localization
E	0031669	biological_process	cellular response to nutrient levels
E	0034198	biological_process	cellular response to amino acid starvation
E	0035556	biological_process	intracellular signal transduction
E	0038202	biological_process	TORC1 signaling
E	0045947	biological_process	negative regulation of translational initiation
E	0045948	biological_process	positive regulation of translational initiation
E	0050890	biological_process	cognition
E	0055085	biological_process	transmembrane transport
E	0061462	biological_process	protein localization to lysosome
E	0070062	cellular_component	extracellular exosome
E	0071397	biological_process	cellular response to cholesterol
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0002181	biological_process	cytoplasmic translation
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0008289	molecular_function	lipid binding
F	0015485	molecular_function	cholesterol binding
F	0016020	cellular_component	membrane
F	0030514	biological_process	negative regulation of BMP signaling pathway
F	0031503	biological_process	protein-containing complex localization
F	0031669	biological_process	cellular response to nutrient levels
F	0034198	biological_process	cellular response to amino acid starvation
F	0035556	biological_process	intracellular signal transduction
F	0038202	biological_process	TORC1 signaling
F	0045947	biological_process	negative regulation of translational initiation
F	0045948	biological_process	positive regulation of translational initiation
F	0050890	biological_process	cognition
F	0055085	biological_process	transmembrane transport
F	0061462	biological_process	protein localization to lysosome
F	0070062	cellular_component	extracellular exosome
F	0071397	biological_process	cellular response to cholesterol
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	244
Details	TOPO_DOM: Lumenal => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	MET1-SER38
F	MET1-SER38
F	SER101-TYR104
F	GLU155-GLN167
F	ARG235-ASN243
F	ARG295-ASN315
F	PRO368-ASN381
F	LYS436-LYS438
F	THR502-GLN520
F	ASN682-GLU691
E	SER101-TYR104
E	GLU155-GLN167
E	ARG235-ASN243
E	ARG295-ASN315
E	PRO368-ASN381
E	LYS436-LYS438
E	THR502-GLN520
E	ASN682-GLU691

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	ILE39-ALA59
F	ILE39-ALA59

site_id	SWS_FT_FI3
Number of Residues	746
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	GLY60-ARG79
F	GLY60-ARG79
F	SER126-LYS133
F	GLU189-ARG213
F	VAL265-LYS273
F	ASN337-GLY346
F	LEU403-LEU414
F	TRP460-PRO480
F	MET542-LEU660
F	LEU713-THR870
E	SER126-LYS133
E	GLU189-ARG213
E	VAL265-LYS273
E	ASN337-GLY346
E	LEU403-LEU414
E	TRP460-PRO480
E	MET542-LEU660
E	LEU713-THR870

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	PHE80-TRP100
F	PHE80-TRP100

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	SER105-ALA125
F	SER105-ALA125

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Discontinuously helical; Name=4 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	ALA134-VAL154
F	ALA134-VAL154

site_id	SWS_FT_FI7
Number of Residues	40
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	TYR168-CYS188
F	TYR168-CYS188

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Discontinuously helical; Name=6 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	VAL214-ASP234
F	VAL214-ASP234

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Discontinuously helical; Name=7 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	PHE244-MET264
F	PHE244-MET264

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	SER274-CYS294
F	SER274-CYS294

site_id	SWS_FT_FI11
Number of Residues	40
Details	TRANSMEM: Discontinuously helical; Name=9 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	TYR316-PHE336
F	TYR316-PHE336

site_id	SWS_FT_FI12
Number of Residues	40
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	MET347-PHE367
F	MET347-PHE367

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	VAL382-LEU402
F	VAL382-LEU402

site_id	SWS_FT_FI14
Number of Residues	40
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	THR415-VAL435
F	THR415-VAL435

site_id	SWS_FT_FI15
Number of Residues	40
Details	TRANSMEM: Helical; Name=13 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	ASN439-LEU459
F	ASN439-LEU459

site_id	SWS_FT_FI16
Number of Residues	40
Details	TRANSMEM: Helical; Name=14 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	VAL481-ILE501
F	VAL481-ILE501

site_id	SWS_FT_FI17
Number of Residues	40
Details	TRANSMEM: Helical; Name=15 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	MET521-CYS541
F	MET521-CYS541

site_id	SWS_FT_FI18
Number of Residues	40
Details	TRANSMEM: Helical; Name=16 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	LEU661-PHE681
F	LEU661-PHE681

site_id	SWS_FT_FI19
Number of Residues	40
Details	TRANSMEM: Helical; Name=17 => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U54, ECO:0007744\|PDB:8U56, ECO:0007744\|PDB:8U58, ECO:0007744\|PDB:8U5C, ECO:0007744\|PDB:8U5N, ECO:0007744\|PDB:8U5Q, ECO:0007744\|PDB:8U5V, ECO:0007744\|PDB:8U5X

Chain	Residue	Details
E	LEU692-GLY712
F	LEU692-GLY712

site_id	SWS_FT_FI20
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:36007018

Chain	Residue	Details
E	PHE43
F	PHE43

site_id	SWS_FT_FI21
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:39358511, ECO:0000305\|PubMed:36007018, ECO:0007744\|PDB:8U5C

Chain	Residue	Details
E	TYR57
F	TYR57

site_id	SWS_FT_FI22
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:39358511, ECO:0007744\|PDB:8U5C

Chain	Residue	Details
E	GLY266
E	LYS267
E	ILE268
E	ARG657
F	GLY266
F	LYS267
F	ILE268
F	ARG657

site_id	SWS_FT_FI23
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN9
F	ASN381
E	ASN15
E	ASN29
E	ASN309
E	ASN381
F	ASN9
F	ASN15
F	ASN29
F	ASN309

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)