Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U5C

The mTORC1 cholesterol sensor LYCHOS (GPR155) with cholesterol

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005765	cellular_component	lysosomal membrane
E	0008289	molecular_function	lipid binding
E	0015485	molecular_function	cholesterol binding
E	0016020	cellular_component	membrane
E	0030514	biological_process	negative regulation of BMP signaling pathway
E	0034198	biological_process	cellular response to amino acid starvation
E	0035556	biological_process	intracellular signal transduction
E	0050890	biological_process	cognition
E	0055085	biological_process	transmembrane transport
E	0070062	cellular_component	extracellular exosome
E	0071397	biological_process	cellular response to cholesterol
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0005765	cellular_component	lysosomal membrane
F	0008289	molecular_function	lipid binding
F	0015485	molecular_function	cholesterol binding
F	0016020	cellular_component	membrane
F	0030514	biological_process	negative regulation of BMP signaling pathway
F	0034198	biological_process	cellular response to amino acid starvation
F	0035556	biological_process	intracellular signal transduction
F	0050890	biological_process	cognition
F	0055085	biological_process	transmembrane transport
F	0070062	cellular_component	extracellular exosome
F	0071397	biological_process	cellular response to cholesterol
F	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	196
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	170
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)