8U1U
Structure of a class A GPCR/agonist complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein | polymer | 743 | 83236.7 | 1 | UniProt (P22362) UniProt (P51685) UniProt (A0A6M5E0N3) Pfam (PF00048) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 376 | 43182.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39518.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | scFv fragment | polymer | 259 | 28124.4 | 1 | Mus musculus (mouse) | ||
| 6 | F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 24 - 93 (UniProt: P22362)
A: 94 - 451 (UniProt: P51685)
A: 474 - 712 (UniProt: A0A6M5E0N3)
B: 1 - 354 (UniProt: P63096)
C: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Cys 38 | Ala 38 | conflict |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 93 | - | linker |
| Gly 93 | - | linker |
| Ser 94 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 117 | Phe 21 | conflict |
| Gly 452 | - | linker |
| Gly 453 | - | linker |
| Ser 454 | - | linker |
| Asp 455 | - | linker |
| Tyr 456 | - | linker |
| Lys 457 | - | linker |
| Asp 458 | - | linker |
| Asp 459 | - | linker |
| Asp 460 | - | linker |
| Asp 461 | - | linker |
| Lys 462 | - | linker |
| Gly 463 | - | linker |
| Gly 464 | - | linker |
| Ser 465 | - | linker |
| Leu 466 | - | linker |
| Glu 467 | - | linker |
| Val 468 | - | linker |
| Leu 469 | - | linker |
| Phe 470 | - | linker |
| Gln 471 | - | linker |
| Gly 472 | - | linker |
| Pro 473 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 520 | Phe 47 | conflict |
| Gly 539 | Thr 66 | conflict |
| Leu 542 | Val 69 | conflict |
| Ala 546 | Ser 73 | conflict |
| Thr 627 | Met 154 | conflict |
| Ala 637 | Val 164 | conflict |
| Gly 649 | Ser 176 | conflict |
| Gln 658 | His 185 | conflict |
| Tyr 677 | Thr 204 | conflict |
| Lys 680 | Ala 207 | conflict |
| Gly 713 | - | expression tag |
| Ser 714 | - | expression tag |
| Ala 715 | - | expression tag |
| Trp 716 | - | expression tag |
| Ser 717 | - | expression tag |
| His 718 | - | expression tag |
| Pro 719 | - | expression tag |
| Gln 720 | - | expression tag |
| Phe 721 | - | expression tag |
| Glu 722 | - | expression tag |
| Lys 723 | - | expression tag |
| Gly 724 | - | expression tag |
| Gly 725 | - | expression tag |
| Gly 726 | - | expression tag |
| Ser 727 | - | expression tag |
| Gly 728 | - | expression tag |
| Gly 729 | - | expression tag |
| Gly 730 | - | expression tag |
| Ser 731 | - | expression tag |
| Gly 732 | - | expression tag |
| Gly 733 | - | expression tag |
| Ser 734 | - | expression tag |
| Ala 735 | - | expression tag |
| Trp 736 | - | expression tag |
| Ser 737 | - | expression tag |
| His 738 | - | expression tag |
| Pro 739 | - | expression tag |
| Gln 740 | - | expression tag |
| Phe 741 | - | expression tag |
| Glu 742 | - | expression tag |
| Lys 743 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| Lys -20 | - | expression tag |
| Lys -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 201922.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 202143.6 |
