8TZD
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-OFS conformation (3DVA analysis)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Sodium/nucleoside cotransporter | polymer | 637 | 71078.3 | 3 | UniProt (F1MGR1) Pfam (PF01773) Pfam (PF07670) Pfam (PF07662) | Bos taurus (cattle) | |
| 2 | D, F, G (A, B, C) | N-hydroxy-5'-O-(2-methylpropanoyl)cytidine | non-polymer | 329.3 | 3 | Chemie (XMO) | |||
| 3 | E (A) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 1 | Chemie (LBN) |
Sequence modifications
A, B, C: 1 - 622 (UniProt: F1MGR1)
| PDB | External Database | Details |
|---|---|---|
| Met -14 | - | initiating methionine |
| Asp -13 | - | expression tag |
| Tyr -12 | - | expression tag |
| Lys -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Thr -2 | - | expression tag |
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 213235.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1748.0 | |
| All* | Total formula weight | 214983.0 |
