8TY1
Cryo-EM structure of coagulation factor VIII bound to NB2E9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Coagulation factor VIII | polymer | 1467 | 168287.0 | 1 | UniProt (P12263) UniProt (P00451) Pfam (PF07732) Pfam (PF00394) Pfam (PF07731) Pfam (PF00754) In PDB | Sus scrofa (pig) | Procoagulant component |
| 2 | B | NB2E9 light chain | polymer | 216 | 23513.2 | 1 | Homo sapiens (human) | ||
| 3 | C | NB2E9 heavy chain | polymer | 235 | 25373.3 | 1 | Homo sapiens (human) | ||
| 4 | D, E, F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) |
Sequence modifications
A: -18 - 372 (UniProt: P12263)
A: 373 - 1636 (UniProt: P00451)
A: 1637 - 2019 (UniProt: P12263)
A: 2020 - 2332 (UniProt: P00451)
A: 373 - 1636 (UniProt: P00451)
| PDB | External Database | Details |
|---|---|---|
| Ala 1627 | Ser 762 | conflict |
| Pro 1632 | His 767 | conflict |
| Ala 1635 | Thr 770 | conflict |
| Ser 1636 | Arg 771 | conflict |
A: 2020 - 2332 (UniProt: P00451)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 217173.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2246.0 | |
| All* | Total formula weight | 219419.5 |
