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8TY1

Cryo-EM structure of coagulation factor VIII bound to NB2E9

Functional Information from GO Data
ChainGOidnamespacecontents
A0005507molecular_functioncopper ion binding
A0016491molecular_functionoxidoreductase activity
Functional Information from PROSITE/UniProt
site_idPS00079
Number of Residues21
DetailsMULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshHhGGMeahV
ChainResidueDetails
AGLY305-VAL325
AGLY686-LEU706
AGLY1994-PHE2014

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH
ChainResidueDetails
CTYR218-HIS224
BTYR194-HIS200

site_idPS01285
Number of Residues28
DetailsFA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG
ChainResidueDetails
AALA2061-GLY2088
AALA2218-GLY2247

site_idPS01286
Number of Residues17
DetailsFA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC
ChainResidueDetails
APRO2153-CYS2169
APRO2310-CYS2326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by thrombin => ECO:0000250
ChainResidueDetails
AARG372
AARG1689

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage (activation) => ECO:0000250
ChainResidueDetails
AARG1648

site_idSWS_FT_FI3
Number of Residues14
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN214
AVAL2130
APHE2200
ALEU2273
AASN1810
AASN2118
AASN240
AASP1794
AGLY1850
ATYR1890
ATYR1976
ATRP2046
AVAL2073
ALYS2110

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by thrombin
ChainResidueDetails
AARG1624

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977
ChainResidueDetails
ATYR1602
ATYR1603
ATYR1607

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN582

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PDB entries from 2024-11-06

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