8TTM

IgG1 Fc Heterodimer combYSelect1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Immunoglobulin gamma-1 heavy chain	polymer	232	26146.6	1	UniProt (P0DOX5) Pfam (PF07654) In PDB	Homo sapiens x Mus musculus hybrid cell line
2	B	Immunoglobulin gamma-1 heavy chain	polymer	232	26148.6	1	UniProt (P0DOX5) Pfam (PF07654) In PDB	Homo sapiens x Mus musculus hybrid cell line
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	2	In PDB GlyTouCan (G80858MF)
4		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 216 - 447 (UniProt: P0DOX5)

PDB	External Database	Details
Ser 409	Lys 411	engineered mutation
Tyr 411	Thr 413	engineered mutation

B: 216 - 447 (UniProt: P0DOX5)

PDB	External Database	Details
Ser 368	Leu 370	engineered mutation
Tyr 399	Asp 401	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52295.1
Branched	Number of molecules	2
	Total formula weight	2926.7
All*	Total formula weight	55221.8

*Water molecules are not included.