8TRQ
T cell recognition of citrullinated vimentin peptide presented by HLA-DR4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 189 | 21919.6 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen, DRB1 beta chain | polymer | 199 | 23206.8 | 1 | UniProt (P01911) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | Human leukocyte antigen DRB1,HLA-DRB1 |
| 3 | C (C) | Vimentin | polymer | 13 | 1438.6 | 1 | UniProt (P08670) | Homo sapiens | |
| 4 | D (D) | A07 TCR alpha chain | polymer | 209 | 22991.3 | 1 | Mus musculus (mouse) | ||
| 5 | E (E) | A07 TCR beta chain | polymer | 245 | 27647.8 | 1 | Mus musculus (mouse) | ||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G, H, I, J, K... (A, B, D, E) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 8 | Q, R, S, T (A, B, D, E) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 5 - 181 (UniProt: P01903)
B: 1 - 190 (UniProt: P01911)
| PDB | External Database | Details |
|---|---|---|
| Ile 1 | - | expression tag |
| Lys 2 | - | expression tag |
| Glu 3 | - | expression tag |
| Glu 4 | - | expression tag |
| Thr 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Asp 185 | - | expression tag |
| Asp 186 | - | expression tag |
| Asp 187 | - | expression tag |
| Asp 188 | - | expression tag |
| Lys 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 9 | Trp 38 | variant |
| Val 11 | Pro 40 | variant |
| His 13 | Arg 42 | variant |
| His 33 | Asn 62 | variant |
| Tyr 37 | Ser 66 | variant |
| Tyr 47 | Phe 76 | variant |
| Leu 67 | Ile 96 | variant |
| Lys 71 | Ala 100 | variant |
| Gly 86 | Val 115 | variant |
| Tyr 96 | Gln 125 | variant |
| Glu 98 | Lys 127 | variant |
| Ala 104 | Ser 133 | variant |
| Asn 120 | Ser 149 | variant |
| Arg 133 | Leu 162 | variant |
| Thr 140 | Ala 169 | variant |
| Val 142 | Met 171 | variant |
| Leu 180 | Val 209 | variant |
| Gly 191 | - | expression tag |
| Ser 192 | - | expression tag |
| Gly 193 | - | expression tag |
| Leu 194 | - | expression tag |
| Glu 195 | - | expression tag |
| Val 196 | - | expression tag |
| Leu 197 | - | expression tag |
| Phe 198 | - | expression tag |
| Gln 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 97204.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 920.9 | |
| All* | Total formula weight | 98549.4 |
