8TR8
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | P2X purinoceptor 7 | polymer | 595 | 68472.5 | 3 | UniProt (Q64663) Pfam (PF00864) Pfam (PF20478) | Rattus | |
| 2 | AA, D, P (C, A, B) | N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide | non-polymer | 419.0 | 3 | Chemie (KEI) PubChem (10161381) | |||
| 3 | BA, E, Q (C, A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | CA, DA, F, G, R... (C, A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | EA, FA, H, I, T... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 6 | GA, HA, IA, J, JA... (C, A, B) | PALMITIC ACID | non-polymer | 256.4 | 15 | Chemie (PLM) | Rattus | ||
| 7 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 8 | LA, MA, NA (A, B, C) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 205417.4 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 8175.7 | |
| All* | Total formula weight | 213593.0 |
