8TQW
Structure of human transcriptional Mediator complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | Mediator of RNA polymerase II transcription subunit 27 | polymer | 311 | 35478.7 | 1 | UniProt (Q6P2C8) Pfam (PF11571) | Homo sapiens (human) | Cofactor required for Sp1 transcriptional activation subunit 8,CRSP complex subunit 8,Mediator complex subunit 27,P37 TRAP/SMCC/PC2 subunit,Transcriptional coactivator CRSP34 |
| 2 | B (1) | Mediator of RNA polymerase II transcription subunit 28 | polymer | 178 | 19540.1 | 1 | UniProt (Q9H204) Pfam (PF11594) | Homo sapiens (human) | Endothelial-derived protein 1,Mediator complex subunit 28,Merlin and Grb2-interacting cytoskeletal protein,Magicin,Tumor angiogenesis marker EG-1 |
| 3 | C (2) | Mediator of RNA polymerase II transcription subunit 29 | polymer | 200 | 21089.8 | 1 | UniProt (Q9NX70) Pfam (PF11568) | Homo sapiens (human) | Intersex-like protein,Mediator complex subunit 29 |
| 4 | D (3) | Mediator of RNA polymerase II transcription subunit 30 | polymer | 178 | 20301.2 | 1 | UniProt (Q96HR3) Pfam (PF11315) | Homo sapiens (human) | Mediator complex subunit 30,TRAP/Mediator complex component TRAP25,Thyroid hormone receptor-associated protein 6,Thyroid hormone receptor-associated protein complex 25 kDa component,Trap25 |
| 5 | E (4) | Mediator of RNA polymerase II transcription subunit 31 | polymer | 131 | 15826.1 | 1 | UniProt (Q9Y3C7) Pfam (PF05669) | Homo sapiens (human) | Mediator complex subunit 31,Mediator complex subunit SOH1,hSOH1 |
| 6 | F (A) | Mediator of RNA polymerase II transcription subunit 1 | polymer | 1581 | 168697.3 | 1 | UniProt (Q15648) Pfam (PF10744) | Homo sapiens (human) | Activator-recruited cofactor 205 kDa component,ARC205,Mediator complex subunit 1,Peroxisome proliferator-activated receptor-binding protein,PBP,PPAR-binding protein,Thyroid hormone receptor-associated protein complex 220 kDa component,Trap220,Thyroid receptor-interacting protein 2,TR-interacting protein 2,TRIP-2,Vitamin D receptor-interacting protein complex component DRIP205,p53 regulatory protein RB18A |
| 7 | G (B) | Unknown Chain | polymer | 20 | 1720.1 | 1 | Homo sapiens | ||
| 8 | H (D) | Mediator of RNA polymerase II transcription subunit 4 | polymer | 270 | 29781.4 | 1 | UniProt (Q9NPJ6) Pfam (PF10018) | Homo sapiens (human) | Activator-recruited cofactor 36 kDa component,ARC36,Mediator complex subunit 4,TRAP/SMCC/PC2 subunit p36 subunit,Vitamin D3 receptor-interacting protein complex 36 kDa component,DRIP36 |
| 9 | I (F) | Mediator of RNA polymerase II transcription subunit 6 | polymer | 246 | 28464.6 | 1 | UniProt (O75586) Pfam (PF04934) | Homo sapiens (human) | Activator-recruited cofactor 33 kDa component,ARC33,Mediator complex subunit 6,hMed6,Renal carcinoma antigen NY-REN-28 |
| 10 | J (G) | Mediator of RNA polymerase II transcription subunit 7 | polymer | 233 | 27285.3 | 1 | UniProt (O43513) Pfam (PF05983) | Homo sapiens (human) | hMED7,Activator-recruited cofactor 34 kDa component,ARC34,Cofactor required for Sp1 transcriptional activation subunit 9,CRSP complex subunit 9,Mediator complex subunit 7,RNA polymerase transcriptional regulation mediator subunit 7 homolog,Transcriptional coactivator CRSP33 |
| 11 | K (H) | Mediator of RNA polymerase II transcription subunit 8 | polymer | 268 | 29112.9 | 1 | UniProt (Q96G25) Pfam (PF10232) | Homo sapiens (human) | Activator-recruited cofactor 32 kDa component,ARC32,Mediator complex subunit 8 |
| 12 | L (I) | Mediator of RNA polymerase II transcription subunit 9 | polymer | 146 | 16422.8 | 1 | UniProt (Q9NWA0) Pfam (PF07544) | Homo sapiens (human) | Mediator complex subunit 9 |
| 13 | M (J) | Mediator of RNA polymerase II transcription subunit 10 | polymer | 135 | 15711.0 | 1 | UniProt (Q9BTT4) Pfam (PF09748) | Homo sapiens (human) | Mediator complex subunit 10,Transformation-related gene 17 protein,TRG-17,Transformation-related gene 20 protein,TRG-20 |
| 14 | N (K) | Mediator of RNA polymerase II transcription subunit 11 | polymer | 117 | 13145.8 | 1 | UniProt (Q9P086) Pfam (PF10280) | Homo sapiens (human) | Mediator complex subunit 11 |
| 15 | O (N) | Mediator of RNA polymerase II transcription subunit 14 | polymer | 1454 | 160787.6 | 1 | UniProt (O60244) Pfam (PF08638) Pfam (PF22981) Pfam (PF22984) Pfam (PF22983) | Homo sapiens (human) | Activator-recruited cofactor 150 kDa component,ARC150,Cofactor required for Sp1 transcriptional activation subunit 2,CRSP complex subunit 2,Mediator complex subunit 14,RGR1 homolog,hRGR1,Thyroid hormone receptor-associated protein complex 170 kDa component,Trap170,Transcriptional coactivator CRSP150,Vitamin D3 receptor-interacting protein complex 150 kDa component,DRIP150 |
| 16 | P (O) | Mediator of RNA polymerase II transcription subunit 15 | polymer | 788 | 86830.1 | 1 | UniProt (Q96RN5) Pfam (PF09606) Pfam (PF21538) Pfam (PF21539) | Homo sapiens (human) | Activator-recruited cofactor 105 kDa component,ARC105,CTG repeat protein 7a,Mediator complex subunit 15,Positive cofactor 2 glutamine/Q-rich-associated protein,PC2 glutamine/Q-rich-associated protein,TPA-inducible gene 1 protein,TIG-1,Trinucleotide repeat-containing gene 7 protein |
| 17 | Q (P) | Mediator of RNA polymerase II transcription subunit 16 | polymer | 877 | 96908.1 | 1 | UniProt (Q9Y2X0) Pfam (PF00400) Pfam (PF11635) Pfam (PF20718) Pfam (PF20719) | Homo sapiens (human) | Mediator complex subunit 16,Thyroid hormone receptor-associated protein 5,Thyroid hormone receptor-associated protein complex 95 kDa component,Trap95,Vitamin D3 receptor-interacting protein complex 92 kDa component,DRIP92 |
| 18 | R (Q) | Mediator of RNA polymerase II transcription subunit 17 | polymer | 651 | 72984.0 | 1 | UniProt (Q9NVC6) Pfam (PF10156) | Homo sapiens (human) | Activator-recruited cofactor 77 kDa component,ARC77,Cofactor required for Sp1 transcriptional activation subunit 6,CRSP complex subunit 6,Mediator complex subunit 17,Thyroid hormone receptor-associated protein complex 80 kDa component,Trap80,Transcriptional coactivator CRSP77,Vitamin D3 receptor-interacting protein complex 80 kDa component,DRIP80 |
| 19 | S (R) | Mediator of RNA polymerase II transcription subunit 18 | polymer | 208 | 23693.7 | 1 | UniProt (Q9BUE0) Pfam (PF09637) | Homo sapiens (human) | Mediator complex subunit 18,p28b |
| 20 | T (S) | Mediator of RNA polymerase II transcription subunit 19 | polymer | 244 | 26321.1 | 1 | UniProt (A0JLT2) Pfam (PF10278) | Homo sapiens (human) | Lung cancer metastasis-related protein 1,Mediator complex subunit 19 |
| 21 | U (T) | Mediator of RNA polymerase II transcription subunit 20 | polymer | 212 | 23243.8 | 1 | UniProt (Q9H944) Pfam (PF08612) | Homo sapiens (human) | Mediator complex subunit 20,TRF-proximal protein homolog,hTRFP |
| 22 | V (U) | Mediator of RNA polymerase II transcription subunit 21 | polymer | 144 | 15575.2 | 1 | UniProt (Q13503) Pfam (PF11221) | Homo sapiens (human) | Mediator complex subunit 21,RNA polymerase II holoenzyme component SRB7,RNAPII complex component SRB7,hSrb7 |
| 23 | W (V) | Mediator of RNA polymerase II transcription subunit 22 | polymer | 200 | 22243.7 | 1 | UniProt (Q15528) Pfam (PF06179) | Homo sapiens (human) | Mediator complex subunit 22,Surfeit locus protein 5,Surf-5 |
| 24 | X (W) | Mediator of RNA polymerase II transcription subunit 23 | polymer | 1368 | 156652.2 | 1 | UniProt (Q9ULK4) Pfam (PF11573) | Homo sapiens (human) | Activator-recruited cofactor 130 kDa component,ARC130,Cofactor required for Sp1 transcriptional activation subunit 3,CRSP complex subunit 3,Mediator complex subunit 23,Protein sur-2 homolog,hSur-2,Transcriptional coactivator CRSP130,Vitamin D3 receptor-interacting protein complex 130 kDa component,DRIP130 |
| 25 | Y (X) | Mediator of RNA polymerase II transcription subunit 24 | polymer | 989 | 110430.2 | 1 | UniProt (O75448) Pfam (PF11277) | Homo sapiens (human) | Activator-recruited cofactor 100 kDa component,ARC100,Cofactor required for Sp1 transcriptional activation subunit 4,CRSP complex subunit 4,Mediator complex subunit 24,Thyroid hormone receptor-associated protein 4,Thyroid hormone receptor-associated protein complex 100 kDa component,Trap100,hTRAP100,Vitamin D3 receptor-interacting protein complex 100 kDa component,DRIP100 |
| 26 | Z (a) | Cyclin-dependent kinase 8 | polymer | 464 | 53368.7 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (human) | |
| 27 | AA (b) | Cyclin-C | polymer | 283 | 33279.7 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (human) | |
| 28 | BA (c) | Mediator of RNA polymerase II transcription subunit 12 | polymer | 2177 | 243354.9 | 1 | UniProt (Q93074) Pfam (PF09497) Pfam (PF12145) Pfam (PF12144) | Homo sapiens (human) | |
| 29 | CA (d) | Mediator of RNA polymerase II transcription subunit 13 | polymer | 2174 | 239535.9 | 1 | UniProt (Q9UHV7) Pfam (PF18296) Pfam (PF06333) | Homo sapiens (human) | Activator-recruited cofactor 250 kDa component,ARC250,Mediator complex subunit 13,Thyroid hormone receptor-associated protein 1,Thyroid hormone receptor-associated protein complex 240 kDa component,Trap240,Vitamin D3 receptor-interacting protein complex component DRIP250,DRIP250 |
| 30 | DA, EA, FA, GA (0, P, c, d) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 29 |
| Total formula weight | 1807786.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 1808047.7 |
