8TQW

Structure of human transcriptional Mediator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000151	cellular_component	ubiquitin ligase complex
0	0003713	molecular_function	transcription coactivator activity
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005667	cellular_component	transcription regulator complex
0	0005730	cellular_component	nucleolus
0	0005829	cellular_component	cytosol
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0016567	biological_process	protein ubiquitination
0	0016592	cellular_component	mediator complex
0	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
0	0035019	biological_process	somatic stem cell population maintenance
0	0051123	biological_process	RNA polymerase II preinitiation complex assembly
0	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
0	0061630	molecular_function	ubiquitin protein ligase activity
0	0070847	cellular_component	core mediator complex
1	0003779	molecular_function	actin binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005856	cellular_component	cytoskeleton
1	0016020	cellular_component	membrane
1	0016592	cellular_component	mediator complex
1	0030864	cellular_component	cortical actin cytoskeleton
1	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
1	0035019	biological_process	somatic stem cell population maintenance
1	0051123	biological_process	RNA polymerase II preinitiation complex assembly
1	0051151	biological_process	negative regulation of smooth muscle cell differentiation
1	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
1	0070847	cellular_component	core mediator complex
2	0003712	molecular_function	transcription coregulator activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0006357	biological_process	regulation of transcription by RNA polymerase II
2	0016592	cellular_component	mediator complex
2	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
2	0051123	biological_process	RNA polymerase II preinitiation complex assembly
2	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
2	0070847	cellular_component	core mediator complex
3	0000151	cellular_component	ubiquitin ligase complex
3	0003712	molecular_function	transcription coregulator activity
3	0003713	molecular_function	transcription coactivator activity
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0016567	biological_process	protein ubiquitination
3	0016592	cellular_component	mediator complex
3	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
3	0035019	biological_process	somatic stem cell population maintenance
3	0042809	molecular_function	nuclear vitamin D receptor binding
3	0045893	biological_process	positive regulation of DNA-templated transcription
3	0046966	molecular_function	nuclear thyroid hormone receptor binding
3	0051123	biological_process	RNA polymerase II preinitiation complex assembly
3	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0061630	molecular_function	ubiquitin protein ligase activity
3	0070847	cellular_component	core mediator complex
4	0000151	cellular_component	ubiquitin ligase complex
4	0003712	molecular_function	transcription coregulator activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006357	biological_process	regulation of transcription by RNA polymerase II
4	0016567	biological_process	protein ubiquitination
4	0016592	cellular_component	mediator complex
4	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
4	0048147	biological_process	negative regulation of fibroblast proliferation
4	0051123	biological_process	RNA polymerase II preinitiation complex assembly
4	0060173	biological_process	limb development
4	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
4	0061630	molecular_function	ubiquitin protein ligase activity
4	0070847	cellular_component	core mediator complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0000785	cellular_component	chromatin
A	0000902	biological_process	cell morphogenesis
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001223	molecular_function	transcription coactivator binding
A	0001525	biological_process	angiogenesis
A	0001701	biological_process	in utero embryonic development
A	0001889	biological_process	liver development
A	0001892	biological_process	embryonic placenta development
A	0002088	biological_process	lens development in camera-type eye
A	0002154	biological_process	thyroid hormone receptor signaling pathway
A	0003222	biological_process	ventricular trabecula myocardium morphogenesis
A	0003406	biological_process	retinal pigment epithelium development
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006590	biological_process	thyroid hormone generation
A	0006606	biological_process	protein import into nucleus
A	0006702	biological_process	androgen biosynthetic process
A	0007420	biological_process	brain development
A	0007507	biological_process	heart development
A	0007595	biological_process	lactation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009887	biological_process	animal organ morphogenesis
A	0010628	biological_process	positive regulation of gene expression
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016592	cellular_component	mediator complex
A	0016922	molecular_function	nuclear receptor binding
A	0030216	biological_process	keratinocyte differentiation
A	0030224	biological_process	monocyte differentiation
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
A	0031100	biological_process	animal organ regeneration
A	0031490	molecular_function	chromatin DNA binding
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0032993	cellular_component	protein-DNA complex
A	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
A	0033598	biological_process	mammary gland epithelial cell proliferation
A	0035035	molecular_function	histone acetyltransferase binding
A	0035050	biological_process	embryonic heart tube development
A	0035116	biological_process	embryonic hindlimb morphogenesis
A	0035162	biological_process	embryonic hemopoiesis
A	0035357	biological_process	peroxisome proliferator activated receptor signaling pathway
A	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
A	0035855	biological_process	megakaryocyte development
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0042809	molecular_function	nuclear vitamin D receptor binding
A	0042974	molecular_function	nuclear retinoic acid receptor binding
A	0042975	molecular_function	peroxisome proliferator activated receptor binding
A	0043010	biological_process	camera-type eye development
A	0043066	biological_process	negative regulation of apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045023	biological_process	G0 to G1 transition
A	0045444	biological_process	fat cell differentiation
A	0045618	biological_process	positive regulation of keratinocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046966	molecular_function	nuclear thyroid hormone receptor binding
A	0048821	biological_process	erythrocyte development
A	0048822	biological_process	enucleate erythrocyte development
A	0050693	molecular_function	LBD domain binding
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060218	biological_process	hematopoietic stem cell differentiation
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0060335	biological_process	positive regulation of type II interferon-mediated signaling pathway
A	0060744	biological_process	mammary gland branching involved in thelarche
A	0060745	biological_process	mammary gland branching involved in pregnancy
A	0060750	biological_process	epithelial cell proliferation involved in mammary gland duct elongation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070318	biological_process	positive regulation of G0 to G1 transition
A	0070562	biological_process	regulation of vitamin D receptor signaling pathway
A	0070847	cellular_component	core mediator complex
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0071383	biological_process	cellular response to steroid hormone stimulus
A	0097067	biological_process	cellular response to thyroid hormone stimulus
A	0140296	molecular_function	general transcription initiation factor binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1990841	molecular_function	promoter-specific chromatin binding
A	2000347	biological_process	positive regulation of hepatocyte proliferation
A	2001141	biological_process	regulation of RNA biosynthetic process
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0016020	cellular_component	membrane
D	0016592	cellular_component	mediator complex
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0042809	molecular_function	nuclear vitamin D receptor binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0070847	cellular_component	core mediator complex
F	0000151	cellular_component	ubiquitin ligase complex
F	0001223	molecular_function	transcription coactivator binding
F	0003677	molecular_function	DNA binding
F	0003712	molecular_function	transcription coregulator activity
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016020	cellular_component	membrane
F	0016567	biological_process	protein ubiquitination
F	0016592	cellular_component	mediator complex
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0035019	biological_process	somatic stem cell population maintenance
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0070847	cellular_component	core mediator complex
G	0000151	cellular_component	ubiquitin ligase complex
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0016567	biological_process	protein ubiquitination
G	0016592	cellular_component	mediator complex
G	0016604	cellular_component	nuclear body
G	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
G	0035019	biological_process	somatic stem cell population maintenance
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0070847	cellular_component	core mediator complex
H	0000151	cellular_component	ubiquitin ligase complex
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0003712	molecular_function	transcription coregulator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070847	cellular_component	core mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016592	cellular_component	mediator complex
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0070847	cellular_component	core mediator complex
J	0000151	cellular_component	ubiquitin ligase complex
J	0003712	molecular_function	transcription coregulator activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0016592	cellular_component	mediator complex
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0035019	biological_process	somatic stem cell population maintenance
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0061630	molecular_function	ubiquitin protein ligase activity
J	0070847	cellular_component	core mediator complex
K	0000151	cellular_component	ubiquitin ligase complex
K	0003712	molecular_function	transcription coregulator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0016567	biological_process	protein ubiquitination
K	0016592	cellular_component	mediator complex
K	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0070847	cellular_component	core mediator complex
N	0003712	molecular_function	transcription coregulator activity
N	0003713	molecular_function	transcription coactivator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0016020	cellular_component	membrane
N	0016592	cellular_component	mediator complex
N	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0035019	biological_process	somatic stem cell population maintenance
N	0042809	molecular_function	nuclear vitamin D receptor binding
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
O	0003712	molecular_function	transcription coregulator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0006355	biological_process	regulation of DNA-templated transcription
O	0016020	cellular_component	membrane
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0035019	biological_process	somatic stem cell population maintenance
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0070847	cellular_component	core mediator complex
P	0003713	molecular_function	transcription coactivator activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006366	biological_process	transcription by RNA polymerase II
P	0016020	cellular_component	membrane
P	0016592	cellular_component	mediator complex
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0042809	molecular_function	nuclear vitamin D receptor binding
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0046966	molecular_function	nuclear thyroid hormone receptor binding
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0070847	cellular_component	core mediator complex
Q	0000151	cellular_component	ubiquitin ligase complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005667	cellular_component	transcription regulator complex
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016020	cellular_component	membrane
Q	0016567	biological_process	protein ubiquitination
Q	0016592	cellular_component	mediator complex
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0035019	biological_process	somatic stem cell population maintenance
Q	0042809	molecular_function	nuclear vitamin D receptor binding
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046966	molecular_function	nuclear thyroid hormone receptor binding
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0061630	molecular_function	ubiquitin protein ligase activity
Q	0070847	cellular_component	core mediator complex
R	0003712	molecular_function	transcription coregulator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0016592	cellular_component	mediator complex
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
S	0003712	molecular_function	transcription coregulator activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0070847	cellular_component	core mediator complex
T	0003712	molecular_function	transcription coregulator activity
T	0003713	molecular_function	transcription coactivator activity
T	0003899	molecular_function	DNA-directed RNA polymerase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0006351	biological_process	DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006366	biological_process	transcription by RNA polymerase II
T	0016592	cellular_component	mediator complex
T	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
T	0032991	cellular_component	protein-containing complex
T	0035914	biological_process	skeletal muscle cell differentiation
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0070847	cellular_component	core mediator complex
U	0000151	cellular_component	ubiquitin ligase complex
U	0001824	biological_process	blastocyst development
U	0003712	molecular_function	transcription coregulator activity
U	0003713	molecular_function	transcription coactivator activity
U	0003899	molecular_function	DNA-directed RNA polymerase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0016567	biological_process	protein ubiquitination
U	0016592	cellular_component	mediator complex
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0035019	biological_process	somatic stem cell population maintenance
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0061630	molecular_function	ubiquitin protein ligase activity
U	0070847	cellular_component	core mediator complex
V	0003712	molecular_function	transcription coregulator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016592	cellular_component	mediator complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0070847	cellular_component	core mediator complex
W	0003713	molecular_function	transcription coactivator activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005667	cellular_component	transcription regulator complex
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0010628	biological_process	positive regulation of gene expression
W	0016592	cellular_component	mediator complex
W	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
W	0051123	biological_process	RNA polymerase II preinitiation complex assembly
W	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0070847	cellular_component	core mediator complex
W	2000409	biological_process	positive regulation of T cell extravasation
X	0003712	molecular_function	transcription coregulator activity
X	0003713	molecular_function	transcription coactivator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006366	biological_process	transcription by RNA polymerase II
X	0016592	cellular_component	mediator complex
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0035019	biological_process	somatic stem cell population maintenance
X	0042809	molecular_function	nuclear vitamin D receptor binding
X	0045893	biological_process	positive regulation of DNA-templated transcription
X	0046966	molecular_function	nuclear thyroid hormone receptor binding
X	0051123	biological_process	RNA polymerase II preinitiation complex assembly
X	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
X	0070847	cellular_component	core mediator complex
a	0000166	molecular_function	nucleotide binding
a	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
a	0004672	molecular_function	protein kinase activity
a	0004674	molecular_function	protein serine/threonine kinase activity
a	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005730	cellular_component	nucleolus
a	0006468	biological_process	protein phosphorylation
a	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
a	0016301	molecular_function	kinase activity
a	0016592	cellular_component	mediator complex
a	0016740	molecular_function	transferase activity
a	0032991	cellular_component	protein-containing complex
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0051726	biological_process	regulation of cell cycle
a	0106310	molecular_function	protein serine kinase activity
a	1990508	cellular_component	CKM complex
b	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0006357	biological_process	regulation of transcription by RNA polymerase II
b	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
b	0016592	cellular_component	mediator complex
b	0042802	molecular_function	identical protein binding
b	0045023	biological_process	G0 to G1 transition
b	0045746	biological_process	negative regulation of Notch signaling pathway
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	1990508	cellular_component	CKM complex
c	0000151	cellular_component	ubiquitin ligase complex
c	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
c	0001756	biological_process	somitogenesis
c	0001843	biological_process	neural tube closure
c	0003682	molecular_function	chromatin binding
c	0003712	molecular_function	transcription coregulator activity
c	0003713	molecular_function	transcription coactivator activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0006357	biological_process	regulation of transcription by RNA polymerase II
c	0007492	biological_process	endoderm development
c	0007507	biological_process	heart development
c	0008013	molecular_function	beta-catenin binding
c	0014003	biological_process	oligodendrocyte development
c	0014044	biological_process	Schwann cell development
c	0016020	cellular_component	membrane
c	0016567	biological_process	protein ubiquitination
c	0016592	cellular_component	mediator complex
c	0021510	biological_process	spinal cord development
c	0021915	biological_process	neural tube development
c	0035019	biological_process	somatic stem cell population maintenance
c	0036342	biological_process	post-anal tail morphogenesis
c	0042809	molecular_function	nuclear vitamin D receptor binding
c	0045893	biological_process	positive regulation of DNA-templated transcription
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0046966	molecular_function	nuclear thyroid hormone receptor binding
c	0048568	biological_process	embryonic organ development
c	0048702	biological_process	embryonic neurocranium morphogenesis
c	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
c	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
c	0061630	molecular_function	ubiquitin protein ligase activity
c	0090245	biological_process	axis elongation involved in somitogenesis
c	1990403	biological_process	embryonic brain development
c	1990508	cellular_component	CKM complex
d	0000122	biological_process	negative regulation of transcription by RNA polymerase II
d	0003712	molecular_function	transcription coregulator activity
d	0003713	molecular_function	transcription coactivator activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0006357	biological_process	regulation of transcription by RNA polymerase II
d	0016020	cellular_component	membrane
d	0016592	cellular_component	mediator complex
d	0042632	biological_process	cholesterol homeostasis
d	0042809	molecular_function	nuclear vitamin D receptor binding
d	0045893	biological_process	positive regulation of DNA-templated transcription
d	0045944	biological_process	positive regulation of transcription by RNA polymerase II
d	0046966	molecular_function	nuclear thyroid hormone receptor binding
d	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
d	0070328	biological_process	triglyceride homeostasis
d	1990508	cellular_component	CKM complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. SSGMKSSSGLGSSGSL

Chain	Residue	Details
A	SER1240-LEU1255

---

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK

Chain	Residue	Details
a	VAL27-LYS52

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV

Chain	Residue	Details
a	VAL147-VAL159

---

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. MKsSsGLGSSGS

Chain	Residue	Details
A	MET1243-SER1254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
d	SER395
d	SER826
d	SER890

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
d	SER500
a	LYS52

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
d	SER504

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5SWW4

Chain	Residue	Details
d	SER530

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
d	SER537
N	SER1136

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:24275569

Chain	Residue	Details
d	SER1029
A	SER1465

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
c	SER1258
A	THR1457

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
c	SER1269

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine; alternate => ECO:0000250|UniProtKB:A2AGH6

Chain	Residue	Details
c	ARG1899

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:A2AGH6

Chain	Residue	Details
c	ARG1910
A	SER1223

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
c	ARG1994
c	ARG2015

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1207

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1215

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER1347
A	SER1403

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1433

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1440

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1463
A	SER1481
A	SER1482

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1479

---