8TQP
HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Gag polyprotein | polymer | 231 | 25461.3 | 12 | UniProt (B6DRA0) Pfam (PF19317) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | M, N, O, P, Q... (A, B, C, D, E...) | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-{(1R)-2-(3,5-difluorophenyl)-1-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}acetamide | non-polymer | 702.7 | 12 | Chemie (K3L) | |||
| 3 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, I, J, K, L, H: 1 - 231 (UniProt: B6DRA0)
| PDB | External Database | Details |
|---|---|---|
| Cys 14 | Ala 146 | engineered mutation |
| Cys 45 | Glu 177 | engineered mutation |
| Ala 184 | Trp 316 | engineered mutation |
| Ala 185 | Met 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 305535.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 8432.7 | |
| All* | Total formula weight | 313968.0 |
