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8TQC

Structure of the human CDK8 kinase module

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(C)
Mediator of RNA polymerase II transcription subunit 12polymer2177243354.91UniProt (Q93074)
Pfam (PF09497)
Pfam (PF12145)
Pfam (PF12144)
Homo sapiens (human)
2B
(D)
Mediator of RNA polymerase II transcription subunit 13polymer2174239535.91UniProt (Q9UHV7)
Pfam (PF18296)
Pfam (PF06333)
Homo sapiens (human)Activator-recruited cofactor 250 kDa component,ARC250,Mediator complex subunit 13,Thyroid hormone receptor-associated protein 1,Thyroid hormone receptor-associated protein complex 240 kDa component,Trap240,Vitamin D3 receptor-interacting protein complex component DRIP250,DRIP250
3C
(A)
Cyclin-dependent kinase 8polymer46453368.71UniProt (P49336)
Pfam (PF00069)
Homo sapiens (human)
4D
(B)
Cyclin-Cpolymer28333279.71UniProt (P24863)
Pfam (PF00134)
Pfam (PF16899)
Homo sapiens (human)
5E, F
(C, D)
ZINC IONnon-polymer65.42Chemie (ZN)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight569539.2
Non-Polymers*Number of molecules2
Total formula weight130.8
All*Total formula weight569670.0
*Water molecules are not included.

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PDB entries from 2025-10-15

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